Technology Process of α-(4-phenylpiperidin-2(a)-yl)benzyl 2,2-diethylbutanoate
There total 21 articles about α-(4-phenylpiperidin-2(a)-yl)benzyl 2,2-diethylbutanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: thionyl chloride
2: 99 percent / sodium carbonate / H2O; diethyl ether / 4 h
3: 1.) TMEDA, sec-BuLi / 1.) ether, 0 deg C, 1 h; 2.) -78 deg C -> ambient temp.
With
thionyl chloride; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; sodium carbonate;
In
diethyl ether; water;
DOI:10.1021/ja00316a033
- Guidance literature:
-
Multi-step reaction with 6 steps
1: thionyl chloride
2: 99 percent / sodium carbonate / H2O; diethyl ether / 4 h
3: 1.) TMEDA, sec-BuLi / 1.) ether, 0 deg C, 1 h; 2.) -78 deg C -> ambient temp.
4: 90 percent / sodium acetate, pyridinium chlorochromate / CH2Cl2 / 2 h
5: 81 percent / sodium methoxide / methanol / 2 h / Heating
6: cc. HCl / methanol
With
hydrogenchloride; thionyl chloride; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; sodium methylate; sodium acetate; sodium carbonate; pyridinium chlorochromate;
In
methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/ja00316a033
- Guidance literature:
-
Multi-step reaction with 6 steps
1: thionyl chloride
2: 99 percent / sodium carbonate / H2O; diethyl ether / 4 h
3: 1.) TMEDA, sec-BuLi / 1.) ether, 0 deg C, 1 h; 2.) -78 deg C -> ambient temp.
4: 90 percent / sodium acetate, pyridinium chlorochromate / CH2Cl2 / 2 h
5: 81 percent / sodium methoxide / methanol / 2 h / Heating
6: cc. HCl / methanol
With
hydrogenchloride; thionyl chloride; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; sodium methylate; sodium acetate; sodium carbonate; pyridinium chlorochromate;
In
methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/ja00316a033
