C₂₀H₁₈N₂O₄

Base Information

• Chemical Name: C₂₀H₁₈N₂O₄
• CAS No.: 1357162-41-4
• Molecular Formula: C₂₀H₁₈N₂O₄
• Molecular Weight: 350.374
• Mol file: 1357162-41-4.mol

Synonyms:

Chemical Property of C₂₀H₁₈N₂O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₁₈N₂O₄

There total 4 articles about C₂₀H₁₈N₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5-methoxy-1-methyl-1H-benzo[d]imidazol-2-yl)methanol (68426-83-5) → C20H18N2O4 (1357162-41-4)

Guidance literature:

Multi-step reaction with 3 steps

1: Dess-Martin periodane / dichloromethane / 6 h / 0 °C

2: boron tribromide / dichloromethane / -78 °C

3: potassium hydroxide / ethanol / 10 h / Cooling with ice

With boron tribromide; Dess-Martin periodane; potassium hydroxide; In ethanol; dichloromethane; 1: Dess-Martin oxidation / 3: Aldol condensation;

DOI:10.1016/j.bmcl.2011.12.074

Reference yield:

4-methoxy-1,2-phenylenediamine (102-51-2) → C20H18N2O4 (1357162-41-4)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogenchloride / water / 6 h / Reflux

2: tetrabutylammomium bromide; potassium hydroxide / tetrahydrofuran / 0 °C

3: Dess-Martin periodane / dichloromethane / 6 h / 0 °C

4: boron tribromide / dichloromethane / -78 °C

5: potassium hydroxide / ethanol / 10 h / Cooling with ice

With hydrogenchloride; tetrabutylammomium bromide; boron tribromide; Dess-Martin periodane; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; 3: Dess-Martin oxidation / 5: Aldol condensation;

DOI:10.1016/j.bmcl.2011.12.074

Reference yield:

(5-methoxy-1H-benzimidazole-2-yl)-methanol (20033-99-2) → C20H18N2O4 (1357162-41-4)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrabutylammomium bromide; potassium hydroxide / tetrahydrofuran / 0 °C

2: Dess-Martin periodane / dichloromethane / 6 h / 0 °C

3: boron tribromide / dichloromethane / -78 °C

4: potassium hydroxide / ethanol / 10 h / Cooling with ice

With tetrabutylammomium bromide; boron tribromide; Dess-Martin periodane; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; 2: Dess-Martin oxidation / 4: Aldol condensation;

DOI:10.1016/j.bmcl.2011.12.074

upstream raw materials:

5-methoxy-1-methyl-1H-1,3-benzodiazole-2-carbaldehyde

(5-methoxy-1-methyl-1H-benzo[d]imidazol-2-yl)methanol

4-methoxy-1,2-phenylenediamine

(5-methoxy-1H-benzimidazole-2-yl)-methanol

Refernces