C₃₇H₄₁N₂O₇P

Base Information

• Chemical Name: C₃₇H₄₁N₂O₇P
• CAS No.: 116589-12-9
• Molecular Formula: C₃₇H₄₁N₂O₇P
• Molecular Weight: 656.716
• Mol file: 116589-12-9.mol

Synonyms:

Chemical Property of C₃₇H₄₁N₂O₇P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₇H₄₁N₂O₇P

There total 21 articles about C₃₇H₄₁N₂O₇P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dimethoxy-3-methylbenzaldehyde (7149-92-0) → C37H41N2O7P (116589-12-9)

Guidance literature:

Multi-step reaction with 19 steps

1: 80 percent / Br₂

2: 1.) m-chloroperbenzoic acid, 2.) KOH / 2.) MeOH

3: NaH / dimethylformamide

4: n-BuLi, perchloryl fluoride / diethyl ether

5: HCl / acetone

6: 83 percent / K₂CO₃ / acetone

7: 62 percent / AlCl₃*OEt₂ / CH₂Cl₂ / 1 h / -25 °C

8: NaH

9: 55 percent / n-BuLi / tetrahydrofuran / -75 - 0 °C

10: 69 percent / cerium(IV) ammonium nitrate / H₂O; acetonitrile / 0.05 h / 0 °C

11: 88 percent / NaN₃ / H₂O; methanol / 1 h

12: 49 percent / Cu(acac)2 / benzene / 2 h / 80 °C

13: 1.) zinc powder, AcOH, 2.) K₂CO₃ / 1.) CH₂Cl₂, 2.) DMF, reflux 12 h

14: 76 percent / N-methylmorpholine oxide / OsO₄ / H₂O; 2-methyl-propan-2-ol / 12 h

15: Et₃N / CH₂Cl₂ / 2 h / 0 °C

16: 56 percent / n-Bu₄NN₃ / benzene / 3 h / Heating

17: Et₃N / CH₂Cl₂ / 2 h / 0 °C

18: tetrahydrofuran / 4 h / Heating

19: NaH(60wtpercent) / tetrahydrofuran / 4 h

With hydrogenchloride; copper acetylacetonate; potassium hydroxide; n-butyllithium; sodium azide; ammonium cerium(IV) nitrate; perchloryl fluoride; AlCl₃ etherate; bromine; tetrabutylammoniun azide; sodium hydride; potassium carbonate; acetic acid; 4-methylmorpholine N-oxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; zinc; osmium(VIII) oxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile; tert-butyl alcohol; benzene;

Reference yield:

Benzyloxymethyl chloride (3587-60-8) → C37H41N2O7P (116589-12-9)

Guidance literature:

Multi-step reaction with 11 steps

1: 55 percent / n-BuLi / tetrahydrofuran / -75 - 0 °C

2: 69 percent / cerium(IV) ammonium nitrate / H₂O; acetonitrile / 0.05 h / 0 °C

3: 88 percent / NaN₃ / H₂O; methanol / 1 h

4: 49 percent / Cu(acac)2 / benzene / 2 h / 80 °C

5: 1.) zinc powder, AcOH, 2.) K₂CO₃ / 1.) CH₂Cl₂, 2.) DMF, reflux 12 h

6: 76 percent / N-methylmorpholine oxide / OsO₄ / H₂O; 2-methyl-propan-2-ol / 12 h

7: Et₃N / CH₂Cl₂ / 2 h / 0 °C

8: 56 percent / n-Bu₄NN₃ / benzene / 3 h / Heating

9: Et₃N / CH₂Cl₂ / 2 h / 0 °C

10: tetrahydrofuran / 4 h / Heating

11: NaH(60wtpercent) / tetrahydrofuran / 4 h

With copper acetylacetonate; n-butyllithium; sodium azide; ammonium cerium(IV) nitrate; tetrabutylammoniun azide; sodium hydride; potassium carbonate; acetic acid; 4-methylmorpholine N-oxide; triethylamine; zinc; osmium(VIII) oxide; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; tert-butyl alcohol; benzene;

Reference yield:

2,6-dimethoxytoluene (5673-07-4) → C37H41N2O7P (116589-12-9)

Guidance literature:

Multi-step reaction with 20 steps

1: 82 percent / TiCl₄

2: 80 percent / Br₂

3: 1.) m-chloroperbenzoic acid, 2.) KOH / 2.) MeOH

4: NaH / dimethylformamide

5: n-BuLi, perchloryl fluoride / diethyl ether

6: HCl / acetone

7: 83 percent / K₂CO₃ / acetone

8: 62 percent / AlCl₃*OEt₂ / CH₂Cl₂ / 1 h / -25 °C

9: NaH

10: 55 percent / n-BuLi / tetrahydrofuran / -75 - 0 °C

11: 69 percent / cerium(IV) ammonium nitrate / H₂O; acetonitrile / 0.05 h / 0 °C

12: 88 percent / NaN₃ / H₂O; methanol / 1 h

13: 49 percent / Cu(acac)2 / benzene / 2 h / 80 °C

14: 1.) zinc powder, AcOH, 2.) K₂CO₃ / 1.) CH₂Cl₂, 2.) DMF, reflux 12 h

15: 76 percent / N-methylmorpholine oxide / OsO₄ / H₂O; 2-methyl-propan-2-ol / 12 h

16: Et₃N / CH₂Cl₂ / 2 h / 0 °C

17: 56 percent / n-Bu₄NN₃ / benzene / 3 h / Heating

18: Et₃N / CH₂Cl₂ / 2 h / 0 °C

19: tetrahydrofuran / 4 h / Heating

20: NaH(60wtpercent) / tetrahydrofuran / 4 h

With hydrogenchloride; copper acetylacetonate; potassium hydroxide; n-butyllithium; sodium azide; ammonium cerium(IV) nitrate; perchloryl fluoride; AlCl₃ etherate; bromine; tetrabutylammoniun azide; titanium tetrachloride; sodium hydride; potassium carbonate; acetic acid; 4-methylmorpholine N-oxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; zinc; osmium(VIII) oxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile; tert-butyl alcohol; benzene;

upstream raw materials:

Methanesulfonic acid (1R,2R,9S,9aS)-5,8-bis-benzyloxy-9-benzyloxymethyl-2-(dimethoxy-phosphorylamino)-7-methoxy-6-methyl-2,3,9,9a-tetrahydro-1H-pyrrolo[1,2-a]indol-1-yl ester

Benzyloxymethyl chloride

2,4-dimethoxy-3-methylbenzaldehyde

2,6-dimethoxytoluene

Downstream raw materials:

4,7-Dibenzyloxy-8β-benzyloxymethyl-1,1aα,2,8,8aβ,8b-hexahydro-6-methoxy-5-methylazirino<2',3';3,4>pyrrolo<1,2-a>indole