7149-92-0

Basic information

• Product Name: 2,4-DIMETHOXY-3-METHYLBENZALDEHYDE
• Synonyms: 2,4-DIMETHOXY-3-METHYLBENZALDEHYDE;2,4-Dimethoxy-3-methylbenzaldehyde 99%
• CAS NO: 7149-92-0
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.2
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);Aldehydes;C10 to C21;Carbonyl Compounds;Building Blocks;C10-C12;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 7149-92-0.mol
• Article Data: 24

Chemical Properties

• Melting Point: 52-54 °C(lit.)
• Boiling Point: 300.4°Cat760mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 1.089g/cm³
• Vapor Pressure: 0.00112mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: soluble in Methanol
• CAS DataBase Reference: 2,4-DIMETHOXY-3-METHYLBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIMETHOXY-3-METHYLBENZALDEHYDE(7149-92-0)
• EPA Substance Registry System: 2,4-DIMETHOXY-3-METHYLBENZALDEHYDE(7149-92-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 7149-92-0(Hazardous Substances Data)

Usage

Uses

2,4-Dimethoxy-3-methylbenzaldehyde has been used:as starting reagent in stereocontrolled total synthesis of (?)-kendomycinin total syntheses of renierol, renierol acetate and renierol propionate

InChI:InChI=1/C10H12O3/c1-7-9(12-2)5-4-8(6-11)10(7)13-3/h4-6H,1-3H3

Upstream product

• 5673-07-4 2,6-dimethoxytoluene 
• 608-25-3 2-methylbenzene-1,3-diol 
• 107-30-2 chloromethyl methyl ether 
• 6248-20-0 2,4-dihydroxy-3-methylbenzaldehyde 
• 77-78-1 dimethyl sulfate 
• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 74-88-4 methyl iodide 
• 4885-02-3 Dichloromethyl methyl ether 
• 93-61-8 N-methyl-N-phenylformamide 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 139122-89-7 1,3-Dimethoxy-2-methyl-4-((E)-2-nitro-vinyl)-benzene 
• 685895-48-1 6-bromo-2,4-dimethoxy-3-methylbenzaldehyde 
• 685895-45-8 2-bromo-4,6-dihydroxy-5-methylbenzaldehyde 
• 94823-71-9 2,4-Dimethoxy-3-methyl-phenylethylamin 
• 113966-99-7 Benzyl-[2-(2,4-dimethoxy-3-methyl-phenyl)-ethyl]-amine 
• 113967-09-2 2-Benzyl-5,7-dimethoxy-6-methyl-1,2,3,4-tetrahydro-isoquinoline 
• 113967-04-7 Benzyl-[2-(2,4-dimethoxy-3-methyl-phenyl)-ethyl]-ethoxymethyl-amine 
• 78647-58-2 4,6-dimethoxy-3,5-dimethyl-2-(1-methyl-2-oxopropyl)benz<2H>aldehyde 
• 78647-69-5 4,6-dimethoxy-3,5-di<3-2H>methyl-2-(1-methyl-2-oxopropyl)benzaldehyde 
• 78647-57-1 4,6-dihydroxy-3,5-di<3-2H>methyl-2-(1-methyl-2-oxopropyl)benzaldehyde 
• 75593-14-5 4,6-dihydroxy-3,5-dimethyl-2-(1-methyl-2-oxopropyl)-benzaldehyde 
• 19314-94-4 6,8-dihydroxy-3,4,5,7-tetramethyl-3,4-dihydroisocoumarin 
• 78647-63-9 2,4-dimethoxy-3-methyl-<α-2H>toluene 
• 42179-86-2 4,6-dimethoxy-3,5-dimethyl-2-(1-methyl-2-oxopropyl)benzaldehyde 

Relevant articles and documents

Azaphilones as Activation-Free Primary-Amine-Specific Bioconjugation Reagents for Peptides, Proteins and Lipids

Residue-selective bioconjugation methods for biomolecules are highly sought to expand the scope of their biological and medical applications. Inspired by the mechanism of the generation of natural vinylogous γ-pyridones (vPDNs), we have developed a novel

Enantioselective Synthesis of (+)-Mitomycin K by a Palladium-Catalyzed Oxidative Tandem Cyclization

The mitomycins, a family of bioactive natural products, feature a compact 6/5/5-fused polycyclic ring structure densely decorated with highly reactive and/or fragile quinone, amino ketal, and aziridine as well as carbamate moieties. It is this striking feature that has defeated numerous synthetic attempts towards these apparently small molecules, rendering them one of the most formidable targets for total synthesis. We herein report the first enantioselective synthesis of (+)-mitomycin K, a representative of G series mitomycins. The key step of this synthesis is an enantioselective oxidative cyclization catalyzed by a palladium/(+)-sparteine system that had previously been developed by our group. The robustness of this method bodes well for further applications in the asymmetric total synthesis of natural products, particularly those with characteristic 6/5/5-fused pyrroloindole skeletons.

Total synthesis of (-)-lemonomycin

When life gives you lemons: An efficient and convergent enantioselective total synthesis of (-)-lemonomycin, which shows potent activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREF), is presented. The key reaction steps are a Hosomi-Sakurai-type cyclization, a thermodynamically controlled Pictet-Spengler reaction, and a glycosidation reaction with lemonose (see scheme). Copyright