(R)-o-methylbenzhydrol

Base Information

• Chemical Name: (R)-o-methylbenzhydrol
• CAS No.: 127309-00-6
• Molecular Formula: C₁₄H₁₄O
• Molecular Weight: 198.265
• Mol file: 127309-00-6.mol

Synonyms:

Chemical Property of (R)-o-methylbenzhydrol

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-o-methylbenzhydrol

There total 53 articles about (R)-o-methylbenzhydrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Methylbenzophenone (131-58-8) → (R)-o-methylbenzhydrol (1517-59-5,5472-13-9,127309-00-6,1517-58-4)

Guidance literature:

With C₃₈H₃₈IrN₄S₂⁽¹⁺⁾*F₆P^(1-); ammonium formate; 3-methyl-5-p-methoxyphenyl-1-hydropyrazole; In tetrahydrofuran; water; at 40 ℃; for 24h; enantioselective reaction;

DOI:10.1039/c6cc00972g

Reference yield: 98.0%

2-Methylbenzophenone (131-58-8) → (R)-o-methylbenzhydrol (1517-59-5,5472-13-9,127309-00-6,1517-58-4) + 2-methyl-(S)-benzhydrol (1517-59-5)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; N-((1R,2R)-2-(((R)-1-(2-(bis(3,5-dimethylphenyl)phosphanyl)ferrocenyl)ethyl)amino)cyclohexyl)-2,4,6-trimethylbenzenesulfonamide; hydrogen; lithium tert-butoxide; In isopropyl alcohol; at 25 - 30 ℃; for 12h; under 22801.5 Torr; enantioselective reaction; Autoclave;

DOI:10.1021/acs.joc.8b01276

Reference yield: 97.0%

phenyltriisopropoxytitanium(IV) (16635-23-7) + 2-methylphenyl aldehyde (529-20-4) → (R)-o-methylbenzhydrol (1517-59-5,5472-13-9,127309-00-6,1517-58-4)

Guidance literature:

phenyltriisopropoxytitanium(IV); With (1R,2S)-2-(4-methylbenzenesulfonylamino)-1,3-diphenyl-1-propanol; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

2-methylphenyl aldehyde; In tetrahydrofuran; at 0 ℃; enantioselective reaction; Inert atmosphere;

DOI:10.1039/c4ra14173c

upstream raw materials:

2-Methylbenzophenone

2-methylphenyl aldehyde

diphenylzinc

tert-butyl-diphenyl-(phenyl-o-tolyl-methoxy)-silane

Downstream raw materials:

(R)-N,N-dimethyl-N-{2-[1-(2-methylphenyl)-1-phenylmethoxy]ethyl}amine