2-(3-Aminopyridin-4-yloxy)ethanol

Base Information

• Chemical Name: 2-(3-Aminopyridin-4-yloxy)ethanol
• CAS No.: 1040316-57-1
• Molecular Formula: C₇H₁₀N₂O₂
• Molecular Weight: 154.169
• Mol file: 1040316-57-1.mol

Synonyms:

Chemical Property of 2-(3-Aminopyridin-4-yloxy)ethanol

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-(3-Aminopyridin-4-yloxy)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-(3-Aminopyridin-4-yloxy)ethanol is used as reactant in the synthetic preparation of isonicotinamides as highly selective, brain penetrable, and orally active glycogen synthase kinase 3 inhibitors.

Technology Process of 2-(3-Aminopyridin-4-yloxy)ethanol

There total 2 articles about 2-(3-Aminopyridin-4-yloxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-((3-nitropyridin-4-yl)oxy)ethanol → 2-((3-aminopyridin-4-yl)oxy)ethanol (1040316-57-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; for 3h; under 760.051 Torr; Inert atmosphere;

DOI:10.1021/acs.jmedchem.5b01550

Reference yield:

4-chloro-3-nitropyridine (13091-23-1) → 2-((3-aminopyridin-4-yl)oxy)ethanol (1040316-57-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 65 °C / Inert atmosphere

2: palladium on activated charcoal; hydrogen / methanol / 3 h / 760.05 Torr / Inert atmosphere

With palladium on activated charcoal; hydrogen; potassium carbonate; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.5b01550

upstream raw materials:

4-chloro-3-nitropyridine

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