Technology Process of (6RS,7RS)-<7-(2)H>-5-formyl-5,6,7,8-tetrahydrofolic acid
There total 5 articles about (6RS,7RS)-<7-(2)H>-5-formyl-5,6,7,8-tetrahydrofolic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 79 percent / ascorbic acid, sodium hydroxide, sodium dithionite / H2O / 0.08 h / Ambient temperature
2: (2)H2O / 0.08 h
3: sodium borohydride / H2O / 0.17 h
4: 20 h / Ambient temperature
5: 0.1 M NaOH / H2O / 2 h / 100 °C
6: hydrochloric acid / H2O
With
hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; sodium dithionite; water; ascorbic acid;
In
water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 20 h / Ambient temperature
2: 0.1 M NaOH / H2O / 2 h / 100 °C
3: hydrochloric acid / H2O
With
hydrogenchloride; sodium hydroxide;
In
water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium borohydride / H2O / 0.17 h
2: 20 h / Ambient temperature
3: 0.1 M NaOH / H2O / 2 h / 100 °C
4: hydrochloric acid / H2O
With
hydrogenchloride; sodium hydroxide; sodium tetrahydroborate;
In
water;