7-Iodo-8-methoxyquinoline

Base Information

• Chemical Name: 7-Iodo-8-methoxyquinoline
• CAS No.: 36749-00-5
• Molecular Formula: C₁₀H₈INO
• Molecular Weight: 285.084
• DSSTox Substance ID: DTXSID60569749
• Wikidata: Q82456965
• Mol file: 36749-00-5.mol

Synonyms:7-IODO-8-METHOXYQUINOLINE;36749-00-5;DTXSID60569749;SB71170

Chemical Property of 7-Iodo-8-methoxyquinoline

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 284.96506
• Heavy Atom Count: 13
• Complexity: 176

Purity/Quality:

98.5% ^*data from raw suppliers

7-Iodo-8-methoxyquinoline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C=CC2=C1N=CC=C2)I

Technology Process of 7-Iodo-8-methoxyquinoline

There total 2 articles about 7-Iodo-8-methoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

7-bromo-8-(methyloxy)quinoline (36748-99-9) → 7-iodo-8-methoxyquinoline (36749-00-5)

Guidance literature:

With hydrogenchloride; water; iodine; phenyllithium; In diethyl ether; 1.) -75 deg C, 2.5 h; 2.) -75 deg C, 2 h; 3.) THF, r.t.;

DOI:10.1055/s-1995-4053

Reference yield:

→ 7-iodo-8-methoxyquinoline (36749-00-5)

Guidance literature:

7-Jod-8-chinolinol, CH3I;

DOI:10.1021/jo00798a022

upstream raw materials:

7-bromo-8-(methyloxy)quinoline

Refernces