3-(2-Bromo-3,5-dimethoxy-phenyl)-propionyl chloride

Base Information

• Chemical Name: 3-(2-Bromo-3,5-dimethoxy-phenyl)-propionyl chloride
• CAS No.: 105705-19-9
• Molecular Formula: C₁₁H₁₂BrClO₃
• Molecular Weight: 307.571
• Mol file: 105705-19-9.mol

Synonyms:

Chemical Property of 3-(2-Bromo-3,5-dimethoxy-phenyl)-propionyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-Bromo-3,5-dimethoxy-phenyl)-propionyl chloride

There total 4 articles about 3-(2-Bromo-3,5-dimethoxy-phenyl)-propionyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2-bromo-3,5-dimethoxyphenyl)propanoic acid (105705-37-1) → 3-(2-Bromo-3,5-dimethoxy-phenyl)-propionyl chloride (105705-19-9)

Guidance literature:

With thionyl chloride; In toluene; for 2h; Heating;

Reference yield:

2-bromo-3,5-dimethoxybenzyl chloride (105705-31-5) → 3-(2-Bromo-3,5-dimethoxy-phenyl)-propionyl chloride (105705-19-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 71 percent / tetrahydrofuran / 1 h / Heating

2: 98 percent / 30percent KOH / ethanol / 4 h / Heating

3: 94 percent / 192 °C

4: SOCl₂ / toluene / 2 h / Heating

With potassium hydroxide; thionyl chloride; In tetrahydrofuran; ethanol; toluene;

Reference yield:

2-(2-bromo-3,5-dimethoxybenzyl)propane-1,3-dioic acid (105705-35-9) → 3-(2-Bromo-3,5-dimethoxy-phenyl)-propionyl chloride (105705-19-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / 192 °C

2: SOCl₂ / toluene / 2 h / Heating

With thionyl chloride; In toluene;

upstream raw materials:

3-(2-bromo-3,5-dimethoxyphenyl)propanoic acid

2-bromo-3,5-dimethoxybenzyl chloride

2-(2-bromo-3,5-dimethoxybenzyl)propane-1,3-dioic acid

diethyl 2-(2-bromo-3,5-dimethoxybenzyl)propane-1,3-dione

Downstream raw materials:

benzyl miriquidate

2,4-dimethoxy-66-(3-oxopentyl)benzoic acid

1-(2-bromo-3,5-dimethoxyphenyl)-3,3-diethoxypentane

miriquidic acid

Refernces