Technology Process of 3-[4-(1-adamantyl)phenyl]propionic acid
There total 11 articles about 3-[4-(1-adamantyl)phenyl]propionic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: trifluoroacetic acid / 12 h / 20 °C
2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 22 h / 20 °C / Reflux
3: potassium hydroxide / water; tetrahydrofuran / 20 h / Reflux
4: sodium hydride / tetrahydrofuran / 1.5 h / 20 °C
5: hydrogen; platinum(IV) oxide / 12 h / 20 °C / 2585.81 Torr
6: sodium hydroxide / water; ethanol / 2 h / Reflux
With
platinum(IV) oxide; N-Bromosuccinimide; hydrogen; sodium hydride; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; dibenzoyl peroxide;
In
tetrahydrofuran; tetrachloromethane; ethanol; water;
4: |Horner-Wadsworth-Emmons Olefination;
DOI:10.2174/1570178613666160104233856
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 22 h / 20 °C / Reflux
2: potassium hydroxide / water; tetrahydrofuran / 20 h / Reflux
3: sodium hydride / tetrahydrofuran / 1.5 h / 20 °C
4: hydrogen; platinum(IV) oxide / 12 h / 20 °C / 2585.81 Torr
5: sodium hydroxide / water; ethanol / 2 h / Reflux
With
platinum(IV) oxide; N-Bromosuccinimide; hydrogen; sodium hydride; potassium hydroxide; sodium hydroxide; dibenzoyl peroxide;
In
tetrahydrofuran; tetrachloromethane; ethanol; water;
3: |Horner-Wadsworth-Emmons Olefination;
DOI:10.2174/1570178613666160104233856
