Technology Process of cis-2-(2,2-Dideutero-2-phenylethyl)-4,4',5-trimethoxystilben
There total 6 articles about cis-2-(2,2-Dideutero-2-phenylethyl)-4,4',5-trimethoxystilben which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 66 percent / AlCl3 / 1,2-dichloro-ethane / Heating; 1.) 2 h, reflux; 2.) 2 h, room temperature
2: 87 percent / CH3O(2)H, 40percent NaO(2)H / D2O / 72 h / Ambient temperature
3: 90 percent / amalg. Zn, conc. HCl / acetic acid; toluene; H2O / 24 h / Heating
4: 1.) conc. HCl, conc. H2SO4; 2.) 2N NaOH / 1.) room temperature, 24 h; 2.) 12 h, reflux, dioxane
5: 63 percent / MnO2 / CH2Cl2 / 16 h / Heating
6: 1.) BuLi / 1.) 4 h, r. t., ether, hexane; 2.) 2 h, reflux, ether, hexane
With
hydrogenchloride; manganese(IV) oxide; sodium hydroxide; n-butyllithium; aluminium trichloride; deuteriated sodium hydroxide; amalgamated zinc; deuteromethanol; sulfuric acid;
In
dichloromethane; water; water-d2; acetic acid; 1,2-dichloro-ethane; toluene;
DOI:10.1007/BF00810900
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 87 percent / CH3O(2)H, 40percent NaO(2)H / D2O / 72 h / Ambient temperature
2: 90 percent / amalg. Zn, conc. HCl / acetic acid; toluene; H2O / 24 h / Heating
3: 1.) conc. HCl, conc. H2SO4; 2.) 2N NaOH / 1.) room temperature, 24 h; 2.) 12 h, reflux, dioxane
4: 63 percent / MnO2 / CH2Cl2 / 16 h / Heating
5: 1.) BuLi / 1.) 4 h, r. t., ether, hexane; 2.) 2 h, reflux, ether, hexane
With
hydrogenchloride; manganese(IV) oxide; sodium hydroxide; n-butyllithium; deuteriated sodium hydroxide; amalgamated zinc; deuteromethanol; sulfuric acid;
In
dichloromethane; water; water-d2; acetic acid; toluene;
DOI:10.1007/BF00810900
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) conc. HCl, conc. H2SO4; 2.) 2N NaOH / 1.) room temperature, 24 h; 2.) 12 h, reflux, dioxane
2: 63 percent / MnO2 / CH2Cl2 / 16 h / Heating
3: 1.) BuLi / 1.) 4 h, r. t., ether, hexane; 2.) 2 h, reflux, ether, hexane
With
hydrogenchloride; manganese(IV) oxide; sodium hydroxide; n-butyllithium; sulfuric acid;
In
dichloromethane;
DOI:10.1007/BF00810900
