Acetic acid, [2-[2-(2-aminoethoxy)ethoxy]ethoxy]-

Base Information

• Chemical Name: Acetic acid, [2-[2-(2-aminoethoxy)ethoxy]ethoxy]-
• CAS No.: 134978-99-7
• Molecular Formula: C8H17NO5
• Molecular Weight: 207.227
• DSSTox Substance ID: DTXSID70567650
• Nikkaji Number: J1.550.139A
• Wikidata: Q82453606
• Mol file: 134978-99-7.mol

Synonyms:134978-99-7;Amino-PEG3-CH2CO2H;Amino-PEG3-CH2COOH;H2N-PEG3-CH2COOH;2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)acetic acid;2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]acetic acid;Acetic acid, [2-[2-(2-aminoethoxy)ethoxy]ethoxy]-;2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}acetic acid;MFCD24479841;Amino-PEG3-acetic acid;Amine-PEG3-CH2COOH;NH2-PEG3-CH2COOH;11-amino-3,6,9-trioxaundecanoic acid;SCHEMBL164253;LCZC1156;DTXSID70567650;WLZ3780;AKOS040741113;BP-23635;SY267149;HY-140189;CS-0115122;C70201;{2-[2-(2-Aminoethoxy)ethoxy]ethoxy}acetic acid;EN300-6493697

Chemical Property of Acetic acid, [2-[2-(2-aminoethoxy)ethoxy]ethoxy]-

Chemical Property:

• Boiling Point: 360.3±27.0 °C(Predicted)
• PKA: 3.39±0.10(Predicted)
• PSA: 91.01000
• Density: 1.164±0.06 g/cm3(Predicted)
• LogP: -0.22020
• XLogP3: -3.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 10
• Exact Mass: 207.11067264
• Heavy Atom Count: 14
• Complexity: 142

Purity/Quality:

98%,99%, ^*data from raw suppliers

H2N-PEG3-CH2COOH min.97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(COCCOCCOCC(=O)O)N

Technology Process of Acetic acid, [2-[2-(2-aminoethoxy)ethoxy]ethoxy]-

There total 11 articles about Acetic acid, [2-[2-(2-aminoethoxy)ethoxy]ethoxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

11-azido-3,6,9-trioxaundecanoic acid (172531-37-2) → 2-<2-<2-(aminoethoxy)ethoxy>ethoxy>acetic acid (134978-99-7,139729-28-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1016/j.bmcl.2003.12.079

Reference yield:

Tetraethylene glycol (112-60-7) → 2-<2-<2-(aminoethoxy)ethoxy>ethoxy>acetic acid (134978-99-7,139729-28-5)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / diethyl ether

2: NaN₃ / ethanol / Heating

3: 80 percent / CrO₃; aq. H₂SO₄ / acetone

4: 100 percent / H₂ / Pd/C / ethanol

With chromium(VI) oxide; sodium azide; sulfuric acid; hydrogen; triethylamine; palladium on activated charcoal; In diethyl ether; ethanol; acetone; 3: Jones oxidation;

DOI:10.1016/j.bmcl.2003.12.079

Reference yield:

2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol (86770-67-4) → 2-<2-<2-(aminoethoxy)ethoxy>ethoxy>acetic acid (134978-99-7,139729-28-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / CrO₃; aq. H₂SO₄ / acetone

2: 100 percent / H₂ / Pd/C / ethanol

With chromium(VI) oxide; sulfuric acid; hydrogen; palladium on activated charcoal; In ethanol; acetone; 1: Jones oxidation;

DOI:10.1016/j.bmcl.2003.12.079

upstream raw materials:

11-azido-3,6,9-trioxaundecanoic acid

Tetraethylene glycol

2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol

2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethyl methanesulfonate

Downstream raw materials:

(2-{2-[2-((9H-fluoren-9-ylmethoxycarbonyl)amino)-ethoxy]-ethoxy}-ethoxy)-acetic acid

{2-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-ethoxy}-acetic acid pentafluorophenyl ester

C₁₈H₃₁N₃O₇S

C₂₁H₂₅N₃O₉