C₄₀H₅₉NO₆Si

Base Information

• Chemical Name: C₄₀H₅₉NO₆Si
• CAS No.: 124665-41-4
• Molecular Formula: C₄₀H₅₉NO₆Si
• Molecular Weight: 677.997
• Mol file: 124665-41-4.mol

Synonyms:

Chemical Property of C₄₀H₅₉NO₆Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₀H₅₉NO₆Si

There total 18 articles about C₄₀H₅₉NO₆Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.1%

p-methoxybenzyl chloride (824-94-2) → C40H59NO6Si (124665-41-4) + C48H67NO7Si (124665-52-7)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 1.25h; Yields of byproduct given;

DOI:10.1016/S0040-4020(01)83440-2

Reference yield:

(1R,2S,6S,7S)-2-Benzyloxymethyl-5-oxo-bicyclo[4.2.0]octane-7-carboxylic acid methyl ester (124665-33-4) → C40H59NO6Si (124665-41-4)

Guidance literature:

Multi-step reaction with 15 steps

1: amberlyst 15 / 2 h / 0 °C

2: benzene; diethyl ether / 0.58 h

3: pyridinium p-toluenesulfonate / acetone / 0.33 h / Ambient temperature

4: 84 percent / N-ethyldiisopropylamine / CH₂Cl₂ / 46 h / Ambient temperature

5: sodium hydride / tetrahydrofuran / 6.5 h / Ambient temperature

6: triethylamine / 1.) 0 deg C, 1h; 2.) rt, 36h

7: potassium hydroxide / methanol; H₂O / 2.5 h / Heating

8: 87 percent / hydroxylamine hydrochloride, sodium acetate / methanol / 0.67 h / Heating

9: xylene / 0.83 h / 150 °C

10: sodium hydroxide / ethanol; H₂O / 7.25 h / Heating

11: 84 percent / H₂, (1S)-(+)-10-camphorsulfonic acid / palladium hydroxide on carbon / ethyl acetate / 22.5 h

12: 85 percent / N-ethyldiisopropylamine / 4-dimethylaminopyridine / CH₂Cl₂ / 1.) 0 deg C, 40 min; 2.) rt,1.33 h

13: lithium diisopropylamide / hexane; tetrahydrofuran / 1.) 0 deg C, 50 min; 2.) rt, 50 min

14: 83 percent / n-BuLi / hexane; tetrahydrofuran / 1.1 h / Ambient temperature

15: pyridinium p-toluenesulfonate / dimethylformamide / 0.83 h / Ambient temperature

With potassium hydroxide; sodium hydroxide; n-butyllithium; Amberlyst 15; hydroxylamine hydrochloride; hydrogen; sodium acetate; pyridinium p-toluenesulfonate; sodium hydride; (+)-10-camphorsulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; dmap; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; xylene; benzene;

DOI:10.1016/S0040-4020(01)83440-2

Reference yield:

(1S,5S,6R,8S)-5-Benzyloxymethyl-8-(1-hydroxy-1-methyl-ethyl)-bicyclo[4.2.0]octan-2-one (118378-03-3) → C40H59NO6Si (124665-41-4)

Guidance literature:

Multi-step reaction with 12 steps

1: 84 percent / N-ethyldiisopropylamine / CH₂Cl₂ / 46 h / Ambient temperature

2: sodium hydride / tetrahydrofuran / 6.5 h / Ambient temperature

3: triethylamine / 1.) 0 deg C, 1h; 2.) rt, 36h

4: potassium hydroxide / methanol; H₂O / 2.5 h / Heating

5: 87 percent / hydroxylamine hydrochloride, sodium acetate / methanol / 0.67 h / Heating

6: xylene / 0.83 h / 150 °C

7: sodium hydroxide / ethanol; H₂O / 7.25 h / Heating

8: 84 percent / H₂, (1S)-(+)-10-camphorsulfonic acid / palladium hydroxide on carbon / ethyl acetate / 22.5 h

9: 85 percent / N-ethyldiisopropylamine / 4-dimethylaminopyridine / CH₂Cl₂ / 1.) 0 deg C, 40 min; 2.) rt,1.33 h

10: lithium diisopropylamide / hexane; tetrahydrofuran / 1.) 0 deg C, 50 min; 2.) rt, 50 min

11: 83 percent / n-BuLi / hexane; tetrahydrofuran / 1.1 h / Ambient temperature

12: pyridinium p-toluenesulfonate / dimethylformamide / 0.83 h / Ambient temperature

With potassium hydroxide; sodium hydroxide; n-butyllithium; hydroxylamine hydrochloride; hydrogen; sodium acetate; pyridinium p-toluenesulfonate; sodium hydride; (+)-10-camphorsulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; dmap; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; xylene;

DOI:10.1016/S0040-4020(01)83440-2

upstream raw materials:

2,4-dimethoxybenzaldehyde dimethylacetal

C₃₁H₅₁NO₄Si

p-methoxybenzyl chloride

3,3'-dimethylbutyrolactone

Downstream raw materials:

C₄₈H₆₇NO₇Si

C₄₈H₆₇NO₇Si

C₂₉H₃₂N₂O₃Se

C₄₆H₆₅NO₇SSi