Technology Process of 2-hydroxymethyl-3-phenylpiperidine
There total 6 articles about 2-hydroxymethyl-3-phenylpiperidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 70 percent / 10percent Pd/C / 0.5 h / 300 - 310 °C
2: 84.5 percent / aq. KMnO4 / 6 h / Heating
3: H2 / Adams catalyst / acetic acid / 24 h / 2585.7 Torr
4: thionyl chloride / 1.) -10 to -15 deg C, 3 h, 2.) reflux, 12 h
5: 0.85 g / lithium aluminum hydride (LAH) / diethyl ether / 24 h
With
potassium permanganate; palladium on activated charcoal; lithium aluminium tetrahydride; thionyl chloride; hydrogen;
platinum(IV) oxide;
In
diethyl ether; acetic acid;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 84.5 percent / aq. KMnO4 / 6 h / Heating
2: H2 / Adams catalyst / acetic acid / 24 h / 2585.7 Torr
3: thionyl chloride / 1.) -10 to -15 deg C, 3 h, 2.) reflux, 12 h
4: 0.85 g / lithium aluminum hydride (LAH) / diethyl ether / 24 h
With
potassium permanganate; lithium aluminium tetrahydride; thionyl chloride; hydrogen;
platinum(IV) oxide;
In
diethyl ether; acetic acid;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: H2 / Adams catalyst / acetic acid / 24 h / 2585.7 Torr
2: thionyl chloride / 1.) -10 to -15 deg C, 3 h, 2.) reflux, 12 h
3: 0.85 g / lithium aluminum hydride (LAH) / diethyl ether / 24 h
With
lithium aluminium tetrahydride; thionyl chloride; hydrogen;
platinum(IV) oxide;
In
diethyl ether; acetic acid;
