methyl-3-phenyl-2-picolinate

Base Information

• Chemical Name: methyl-3-phenyl-2-picolinate
• CAS No.: 130943-99-6
• Molecular Formula: C₁₃H₁₇NO₂
• Molecular Weight: 219.283
• Mol file: 130943-99-6.mol

Synonyms:

Chemical Property of methyl-3-phenyl-2-picolinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl-3-phenyl-2-picolinate

There total 5 articles about methyl-3-phenyl-2-picolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-3-phenyl-piperidine (70769-67-4) → methyl-3-phenyl-2-picolinate (130943-99-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 70 percent / 10percent Pd/C / 0.5 h / 300 - 310 °C

2: 84.5 percent / aq. KMnO₄ / 6 h / Heating

3: H₂ / Adams catalyst / acetic acid / 24 h / 2585.7 Torr

4: thionyl chloride / 1.) -10 to -15 deg C, 3 h, 2.) reflux, 12 h

With potassium permanganate; palladium on activated charcoal; thionyl chloride; hydrogen; platinum(IV) oxide; In acetic acid;

Reference yield:

2-methyl-3-phenylpyridine (3256-89-1) → methyl-3-phenyl-2-picolinate (130943-99-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 84.5 percent / aq. KMnO₄ / 6 h / Heating

2: H₂ / Adams catalyst / acetic acid / 24 h / 2585.7 Torr

3: thionyl chloride / 1.) -10 to -15 deg C, 3 h, 2.) reflux, 12 h

With potassium permanganate; thionyl chloride; hydrogen; platinum(IV) oxide; In acetic acid;

Reference yield:

3-phenylpyridine-2-carboxylic acid (103863-15-6) → methyl-3-phenyl-2-picolinate (130943-99-6)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Adams catalyst / acetic acid / 24 h / 2585.7 Torr

2: thionyl chloride / 1.) -10 to -15 deg C, 3 h, 2.) reflux, 12 h

With thionyl chloride; hydrogen; platinum(IV) oxide; In acetic acid;

upstream raw materials:

methanol

3-phenylpiperidine-2-carboxylic acid

2-methyl-3-phenylpyridine

2-methyl-3-phenyl-piperidine

Downstream raw materials:

2-hydroxymethyl-3-phenylpiperidine