1,2-Propanediol, 2-cyclohexyl-, (R)-

Base Information

• Chemical Name: 1,2-Propanediol, 2-cyclohexyl-, (R)-
• CAS No.: 135042-87-4
• Molecular Formula: C₉H₁₈O₂
• Molecular Weight: 158.241
• Mol file: 135042-87-4.mol

Synonyms:

Chemical Property of 1,2-Propanediol, 2-cyclohexyl-, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-Propanediol, 2-cyclohexyl-, (R)-

There total 5 articles about 1,2-Propanediol, 2-cyclohexyl-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

2-cyclohexyl-1,2-propanediol (90676-98-5) + isovaleraldehyde (590-86-3) → (2S,4R)-4-cyclohexyl-2-isobutyl-4-methyl-1,3-dioxolane + (S)-(-)-2-cyclohexylpropane-1,2-diol (90676-98-5,135042-87-4)

Guidance literature:

With C₈₀H₇₃NO₆P₂; In toluene; at 20 ℃; for 15h; enantioselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1021/ja512481d

Reference yield:

cyclohexylmagnesium bromide (931-50-0) → (2S,4R)-4-cyclohexyl-2-isobutyl-4-methyl-1,3-dioxolane + (S)-(-)-2-cyclohexylpropane-1,2-diol (90676-98-5,135042-87-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 0 °C / Inert atmosphere

2: C₈₀H₇₃NO₆P₂ / toluene / 15 h / 20 °C / Inert atmosphere; Molecular sieve

With C₈₀H₇₃NO₆P₂; In tetrahydrofuran; toluene;

DOI:10.1021/ja512481d

Reference yield:

vinylcyclohexane (695-12-5,25498-06-0) → (S)-(-)-2-cyclohexylpropane-1,2-diol (90676-98-5,135042-87-4) + (R)-(+)-2-cyclohexylpropane-1,2-diol (135042-87-4)

Guidance literature:

With potassium dioxotetrahydroxoosmate(VI); potassium carbonate; dihydroquinidine 9-O-(9'-phenanthryl) ether hydrochloride; potassium hexacyanoferrate(III); In water; tert-butyl alcohol; at 0 ℃; for 18h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00015a001

upstream raw materials:

vinylcyclohexane

(R)-1-phenyl-1,2-ethanediol

2-cyclohexyl-1,2-propanediol

isovaleraldehyde