<2R-(2α(Ξ*,S*),3aα,4β,7β,7aα)>-4-<(Octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>-1,3-bis(phenylmethoxy)-2-butanol

Base Information

• Chemical Name: <2R-(2α(Ξ*,S*),3aα,4β,7β,7aα)>-4-<(Octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>-1,3-bis(phenylmethoxy)-2-butanol
• CAS No.: 120687-02-7
• Molecular Formula: C₃₀H₄₀O₅
• Molecular Weight: 480.645
• Mol file: 120687-02-7.mol

Synonyms:

Chemical Property of <2R-(2α(Ξ*,S*),3aα,4β,7β,7aα)>-4-<(Octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>-1,3-bis(phenylmethoxy)-2-butanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <2R-(2α(Ξ*,S*),3aα,4β,7β,7aα)>-4-<(Octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>-1,3-bis(phenylmethoxy)-2-butanol

There total 3 articles about <2R-(2α(Ξ*,S*),3aα,4β,7β,7aα)>-4-<(Octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>-1,3-bis(phenylmethoxy)-2-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

<2R-(2α(1S*(2'S*,3a'R*,4'R*,7'R*,7a'R*),2Ξ*),3aα,4β,7β,7aα)>-2,2'-<<2-(Phenylmethoxy)-1-<(phenylmethoxy)methyl>-1,3-propandiyl>bis(oxy)>bis(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran) (120687-01-6,120786-27-8,120786-28-9) → (2S,2'S-(2α,2'α,3aα,3a'α,4β,4'β,7β,7'β,7aα,7a'α))-2,2'-oxybis[octahydro-7,8,8-trimethyl-4,7-methanobenzofuran] (108031-80-7) + <2R-(2α(Ξ*,S*),3aα,4β,7β,7aα)>-4-<(Octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>-1,3-bis(phenylmethoxy)-2-butanol (120687-02-7,120786-29-0,120786-30-3)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; for 2h;

Reference yield:

benzyl bromide (100-39-0) → <2R-(2α(Ξ*,S*),3aα,4β,7β,7aα)>-4-<(Octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>-1,3-bis(phenylmethoxy)-2-butanol (120687-02-7,120786-29-0,120786-30-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) NaH / 1) DMF, -15 grad C, 1 h; 2) 2 h, room temp.

2: 58 percent / p-TsOH / CH₂Cl₂ / 2 h

With sodium hydride; toluene-4-sulfonic acid; In dichloromethane;

Reference yield:

<2R-(2α(2S*(2'S*,3a'R*,4'R*,7'R*,7a'R*),3Ξ*),3aα,4β,7β,7aα)>-2,4-Bis<(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>-1,3-butandiol (120686-94-4,120786-22-3,120786-23-4,120786-24-5) → <2R-(2α(Ξ*,S*),3aα,4β,7β,7aα)>-4-<(Octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>-1,3-bis(phenylmethoxy)-2-butanol (120687-02-7,120786-29-0,120786-30-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) NaH / 1) DMF, -15 grad C, 1 h; 2) 2 h, room temp.

2: 58 percent / p-TsOH / CH₂Cl₂ / 2 h

With sodium hydride; toluene-4-sulfonic acid; In dichloromethane;

upstream raw materials:

<2R-(2α(1S*(2'S*,3a'R*,4'R*,7'R*,7a'R*),2Ξ*),3aα,4β,7β,7aα)>-2,2'-<<2-(Phenylmethoxy)-1-<(phenylmethoxy)methyl>-1,3-propandiyl>bis(oxy)>bis(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran)

benzyl bromide

<2R-(2α(2S*(2'S*,3a'R*,4'R*,7'R*,7a'R*),3Ξ*),3aα,4β,7β,7aα)>-2,4-Bis<(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>-1,3-butandiol

Downstream raw materials:

(1R,2R,4R,6R,7R)-1,10,10-Trimethyl-4-((S)-2,3,4-tris-benzyloxy-butoxy)-3-oxa-tricyclo[5.2.1.0^2,6]decane