1-<amino>-4-chloro-5-formamidopyromidine

Base Information

• Chemical Name: 1-<amino>-4-chloro-5-formamidopyromidine
• CAS No.: 220842-47-7
• Molecular Formula: C₂₄H₂₅ClN₄O₃
• Molecular Weight: 452.941
• Mol file: 220842-47-7.mol

Synonyms:

Chemical Property of 1-<amino>-4-chloro-5-formamidopyromidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<amino>-4-chloro-5-formamidopyromidine

There total 4 articles about 1-<amino>-4-chloro-5-formamidopyromidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

4,6-dichloro-5-formamidopyrimidine (123240-66-4) + cis-2,cis-3-bis(benzyloxymethyl)cyclopropylamine (220845-67-0) → 1-<amino>-4-chloro-5-formamidopyromidine (220842-47-7)

Guidance literature:

With triethylamine; In 1,4-dioxane; for 8h; Heating;

DOI:10.1016/S0040-4020(98)01120-X

Reference yield:

(1S,2R,3S)-2,3-Bis-benzyloxymethyl-cyclopropanecarbaldehyde (172688-27-6) → 1-<amino>-4-chloro-5-formamidopyromidine (220842-47-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 71 percent / Jones' reagent / acetone / 10 h / -5 °C

2: 1.) ClCO₂Et, Et₃N, 2.) NH₃ / 1.) THF, -5 deg C, 1 h, 2.) THF, 0 deg C, 1 h

3: 78 percent / KOH, PhI(OAc)2 / 1 h / 5 - 20 °C

4: 83 percent / KOH / methanol / 48 h / Heating

5: 50 percent / Et₃N / dioxane / 8 h / Heating

With potassium hydroxide; jones' reagent; [bis(acetoxy)iodo]benzene; ammonia; chloroformic acid ethyl ester; triethylamine; In 1,4-dioxane; methanol; acetone;

DOI:10.1016/S0040-4020(98)01120-X

Reference yield:

cis-2,cis-3-bis(benzyloxymethyl)cyclopropanecarboxylic acid (220845-64-7) → 1-<amino>-4-chloro-5-formamidopyromidine (220842-47-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) ClCO₂Et, Et₃N, 2.) NH₃ / 1.) THF, -5 deg C, 1 h, 2.) THF, 0 deg C, 1 h

2: 78 percent / KOH, PhI(OAc)2 / 1 h / 5 - 20 °C

3: 83 percent / KOH / methanol / 48 h / Heating

4: 50 percent / Et₃N / dioxane / 8 h / Heating

With potassium hydroxide; [bis(acetoxy)iodo]benzene; ammonia; chloroformic acid ethyl ester; triethylamine; In 1,4-dioxane; methanol;

DOI:10.1016/S0040-4020(98)01120-X

upstream raw materials:

4,6-dichloro-5-formamidopyrimidine

cis-2,cis-3-bis(benzyloxymethyl)cyclopropylamine

(1S,2R,3S)-2,3-Bis-benzyloxymethyl-cyclopropanecarbaldehyde

cis-2,cis-3-bis(benzyloxymethyl)cyclopropanecarboxylic acid

Downstream raw materials:

9-adenine

9--6-chloropurine