[(4R,5R)-5-((1S,3R)-4-Benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy]-tert-butyl-dimethyl-silane

Base Information

• Chemical Name: [(4R,5R)-5-((1S,3R)-4-Benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy]-tert-butyl-dimethyl-silane
• CAS No.: 637000-65-8
• Molecular Formula: C₂₅H₄₄O₄Si
• Molecular Weight: 436.707
• Mol file: 637000-65-8.mol

Synonyms:

Chemical Property of [(4R,5R)-5-((1S,3R)-4-Benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy]-tert-butyl-dimethyl-silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(4R,5R)-5-((1S,3R)-4-Benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy]-tert-butyl-dimethyl-silane

There total 2 articles about [(4R,5R)-5-((1S,3R)-4-Benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy]-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) + [(4R,5R)-5-((1S,3R)-4-Benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-methanol → [(4R,5R)-5-((1S,3R)-4-Benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy]-tert-butyl-dimethyl-silane (637000-65-8)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2003.09.136

Reference yield:

(4S,5R)-5-((1S,3R)-4-Benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid ethyl ester (637000-56-7) → [(4R,5R)-5-((1S,3R)-4-Benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy]-tert-butyl-dimethyl-silane (637000-65-8)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran / 0.5 h / 20 °C

2: imidazole / dimethylformamide / 2 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2003.09.136

upstream raw materials:

tert-butyldimethylsilyl chloride

(4S,5R)-5-((1S,3R)-4-Benzyloxy-1,3-dimethyl-butyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid ethyl ester