4-(phosphonophenylmethyl)-2-piperazinecarboxylic acid hydrobromide

Base Information

• Chemical Name: 4-(phosphonophenylmethyl)-2-piperazinecarboxylic acid hydrobromide
• CAS No.: 129365-44-2
• Molecular Formula: 8BrH*5C₁₂H₁₇N₂O₅P
• Molecular Weight: 2148.55
• Mol file: 129365-44-2.mol

Synonyms:

Chemical Property of 4-(phosphonophenylmethyl)-2-piperazinecarboxylic acid hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(phosphonophenylmethyl)-2-piperazinecarboxylic acid hydrobromide

There total 3 articles about 4-(phosphonophenylmethyl)-2-piperazinecarboxylic acid hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperazine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester (126937-43-7,1217598-28-1) → 4-(phosphonophenylmethyl)-2-piperazinecarboxylic acid hydrobromide (129365-44-2,129365-45-3)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 48 h / 80 °C

2: 1.) 1 M aq. NaOH, 2.) (CH₃)3SiBr / 1.) dioxane, 25 deg C, 25 h, 2.) CH₃CN, 25 deg C, 24 h

With sodium hydroxide; trimethylsilyl bromide; In acetonitrile;

DOI:10.1021/jm00172a037

Reference yield:

benzaldehyde (100-52-7) → 4-(phosphonophenylmethyl)-2-piperazinecarboxylic acid hydrobromide (129365-44-2,129365-45-3)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 48 h / 80 °C

2: 1.) 1 M aq. NaOH, 2.) (CH₃)3SiBr / 1.) dioxane, 25 deg C, 25 h, 2.) CH₃CN, 25 deg C, 24 h

With sodium hydroxide; trimethylsilyl bromide; In acetonitrile;

DOI:10.1021/jm00172a037

Reference yield:

2-methyl 1-phenylmethyl 4-<(dimethoxyphosphinyl)phenylmethyl>-1,2-piperazinedicarboxylate (129365-32-8,129365-33-9) → 4-(phosphonophenylmethyl)-2-piperazinecarboxylic acid hydrobromide (129365-44-2,129365-45-3)

Guidance literature:

With sodium hydroxide; trimethylsilyl bromide; Yield given. Multistep reaction; 1.) dioxane, 25 deg C, 25 h, 2.) CH₃CN, 25 deg C, 24 h;

DOI:10.1021/jm00172a037

upstream raw materials:

2-methyl 1-phenylmethyl 4-<(dimethoxyphosphinyl)phenylmethyl>-1,2-piperazinedicarboxylate

piperazine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

benzaldehyde