Phenol, 2-[4-[2-(3-hydroxyphenyl)ethyl]phenoxy]-4-[2-(3-methoxyphenyl)ethyl]-

Base Information

• Chemical Name: Phenol, 2-[4-[2-(3-hydroxyphenyl)ethyl]phenoxy]-4-[2-(3-methoxyphenyl)ethyl]-
• CAS No.: 135203-46-2
• Molecular Formula: C29H28O4
• Molecular Weight: 440.539
• Mol file: 135203-46-2.mol

Synonyms:

Chemical Property of Phenol, 2-[4-[2-(3-hydroxyphenyl)ethyl]phenoxy]-4-[2-(3-methoxyphenyl)ethyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phenol, 2-[4-[2-(3-hydroxyphenyl)ethyl]phenoxy]-4-[2-(3-methoxyphenyl)ethyl]-

There total 7 articles about Phenol, 2-[4-[2-(3-hydroxyphenyl)ethyl]phenoxy]-4-[2-(3-methoxyphenyl)ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.7%

1-Benzyloxy-2-{4-[(E)-2-(3-benzyloxy-phenyl)-vinyl]-phenoxy}-4-[(E)-2-(3-methoxy-phenyl)-vinyl]-benzene (135203-61-1) → perottetin E-11'-methyl ether (135203-46-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; Ambient temperature;

DOI:10.1016/0031-9422(91)84201-3

Reference yield:

4-benzyloxy-3-hydroxy-benzaldehyde (4049-39-2) → perottetin E-11'-methyl ether (135203-46-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 81.3 percent / K₂CO₃, CuO / pyridine / 24 h / Heating

2: 1) KOt-Bu / 1) DMF, 0-5 deg C, 15 min, 2) DMF, 4h, r. t.

3: 99.1 percent / LiAlH₄ / diethyl ether / 4 h / Ambient temperature

4: 95.1 percent / pyridinium dichromate / CH₂Cl₂ / 12 h

5: 1) KOt-Bu / 1) DMF, 0-5 deg C, 15 min, 2) DMF, r. t.

6: 80.7 percent / H₂ / 20percent Pd-C / ethyl acetate / Ambient temperature

With lithium aluminium tetrahydride; dipyridinium dichromate; potassium tert-butylate; hydrogen; potassium carbonate; copper(II) oxide; palladium on activated charcoal; In pyridine; diethyl ether; dichloromethane; ethyl acetate;

DOI:10.1016/0031-9422(91)84201-3

Reference yield:

ethyl 4-(2-benzyloxy-5-formylphenoxy)benzoate (135203-56-4) → perottetin E-11'-methyl ether (135203-46-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 1) KOt-Bu / 1) DMF, 0-5 deg C, 15 min, 2) DMF, 4h, r. t.

2: 99.1 percent / LiAlH₄ / diethyl ether / 4 h / Ambient temperature

3: 95.1 percent / pyridinium dichromate / CH₂Cl₂ / 12 h

4: 1) KOt-Bu / 1) DMF, 0-5 deg C, 15 min, 2) DMF, r. t.

5: 80.7 percent / H₂ / 20percent Pd-C / ethyl acetate / Ambient temperature

With lithium aluminium tetrahydride; dipyridinium dichromate; potassium tert-butylate; hydrogen; palladium on activated charcoal; In diethyl ether; dichloromethane; ethyl acetate;

DOI:10.1016/0031-9422(91)84201-3

upstream raw materials:

1-Benzyloxy-2-{4-[(E)-2-(3-benzyloxy-phenyl)-vinyl]-phenoxy}-4-[(E)-2-(3-methoxy-phenyl)-vinyl]-benzene

Ethyl 4-bromobenzoate

4-benzyloxy-3-hydroxy-benzaldehyde

ethyl 4-(2-benzyloxy-5-formylphenoxy)benzoate

Downstream raw materials:

Acetic acid 2-{4-[2-(3-acetoxy-phenyl)-ethyl]-phenoxy}-4-[2-(3-methoxy-phenyl)-ethyl]-phenyl ester

perrottetin E-11,1'-diethyl-11'-methyl ether

2-Methoxy-4',5-bis<2-(m-methoxyphenethyl)ethenyl>diphenylether

3-ethoxy-4'-hydroxydihydrostilbene