Technology Process of 5'-[2-(5-chloro-4'-hydroxymethyl-4,2'-dimethoxy-biphenyl-2-yl)-ethyl]-6,2'-dimethoxy-biphenyl-3-carbaldehyde
There total 11 articles about 5'-[2-(5-chloro-4'-hydroxymethyl-4,2'-dimethoxy-biphenyl-2-yl)-ethyl]-6,2'-dimethoxy-biphenyl-3-carbaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 89 percent / Br2 / CCl4 / 24 h / 20 °C
2.1: 76 percent / K2CO3 / acetone / 24 h / Heating
3.1: n-BuLi / tetrahydrofuran; hexane; diethyl ether / 0.08 h / -98 °C
3.2: B(OMe)3 / tetrahydrofuran; hexane; diethyl ether / 12 h / -98 - 20 °C
3.3: 65 percent / aq. HCl / tetrahydrofuran; hexane; diethyl ether / 20 °C
4.1: 83 percent / K3PO4 / Pd(PPh3)4 / dimethylformamide / 12 h / 80 °C
5.1: NBS; AIBN / CCl4 / 6 h / Heating
6.1: 4.27 g / acetonitrile / 12 h / Heating
7.1: 72 percent / K2CO3; 18-crown-6 / CH2Cl2 / 24 h / Heating
8.1: 86 percent / H2; Et3N / 5 percent Pd/C / ethyl acetate / 24 h / 2625.21 Torr
9.1: LiAlH4 / diethyl ether / 12 h / Heating
10.1: aq. AcOH / 15 h / 20 °C
With
potassium phosphate; N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; 18-crown-6 ether; 2,2'-azobis(isobutyronitrile); hydrogen; bromine; potassium carbonate; acetic acid; triethylamine;
palladium on activated charcoal; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; tetrachloromethane; diethyl ether; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile;
4.1: Suzuki reaction / 7.1: Wittig reaction;
DOI:10.1055/s-2002-35629
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 83 percent / K3PO4 / Pd(PPh3)4 / dimethylformamide / 12 h / 80 °C
2: NBS; AIBN / CCl4 / 6 h / Heating
3: 4.27 g / acetonitrile / 12 h / Heating
4: 72 percent / K2CO3; 18-crown-6 / CH2Cl2 / 24 h / Heating
5: 86 percent / H2; Et3N / 5 percent Pd/C / ethyl acetate / 24 h / 2625.21 Torr
6: LiAlH4 / diethyl ether / 12 h / Heating
7: aq. AcOH / 15 h / 20 °C
With
potassium phosphate; N-Bromosuccinimide; lithium aluminium tetrahydride; 18-crown-6 ether; 2,2'-azobis(isobutyronitrile); hydrogen; potassium carbonate; acetic acid; triethylamine;
palladium on activated charcoal; tetrakis(triphenylphosphine) palladium(0);
In
tetrachloromethane; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
1: Suzuki reaction / 4: Wittig reaction;
DOI:10.1055/s-2002-35629
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: n-BuLi / tetrahydrofuran; hexane; diethyl ether / 0.08 h / -98 °C
1.2: B(OMe)3 / tetrahydrofuran; hexane; diethyl ether / 12 h / -98 - 20 °C
1.3: 65 percent / aq. HCl / tetrahydrofuran; hexane; diethyl ether / 20 °C
2.1: 83 percent / K3PO4 / Pd(PPh3)4 / dimethylformamide / 12 h / 80 °C
3.1: NBS; AIBN / CCl4 / 6 h / Heating
4.1: 4.27 g / acetonitrile / 12 h / Heating
5.1: 72 percent / K2CO3; 18-crown-6 / CH2Cl2 / 24 h / Heating
6.1: 86 percent / H2; Et3N / 5 percent Pd/C / ethyl acetate / 24 h / 2625.21 Torr
7.1: LiAlH4 / diethyl ether / 12 h / Heating
8.1: aq. AcOH / 15 h / 20 °C
With
potassium phosphate; N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; 18-crown-6 ether; 2,2'-azobis(isobutyronitrile); hydrogen; potassium carbonate; acetic acid; triethylamine;
palladium on activated charcoal; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; tetrachloromethane; diethyl ether; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
2.1: Suzuki reaction / 5.1: Wittig reaction;
DOI:10.1055/s-2002-35629
