4-bromo-2-chloro-5-methylphenol

Base Information

• Chemical Name: 4-bromo-2-chloro-5-methylphenol
• CAS No.: 319473-24-0
• Molecular Formula: C7H6BrClO
• Molecular Weight: 221.481
• Mol file: 319473-24-0.mol

Synonyms:Phenol,4-bromo-2-chloro-5-methyl;

Chemical Property of 4-bromo-2-chloro-5-methylphenol

Chemical Property:

• Melting Point: 70-70.5 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 260.0±35.0 °C(Predicted)
• PKA: 8.05±0.23(Predicted)
• PSA: 20.23000
• Density: 1.674±0.06 g/cm3(Predicted)
• LogP: 3.11650

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-2-chloro-5-methylphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-bromo-2-chloro-5-methylphenol

There total 1 articles about 4-bromo-2-chloro-5-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-chloro-5-methylphenol (615-74-7) → 4-bromo-2-chloro-5-methylphenol (319473-24-0)

Guidance literature:

With benzyltriphenylphosphonium tribromide; calcium carbonate; In methanol; dichloromethane; at 20 ℃; for 1h;

Reference yield: 76.0%

dimethyl sulfate (77-78-1) + 4-bromo-2-chloro-5-methylphenol (319473-24-0) → 1-bromo-5-chloro-4-methoxy-2-methylbenzene (179897-95-1)

Guidance literature:

With potassium carbonate; In acetone; for 24h; Heating;

DOI:10.1055/s-2002-35629

Reference yield: 52.0%

laurylmagnesium bromide (15890-72-9) + 4-bromo-2-chloro-5-methylphenol (319473-24-0) → 4-bromo-2-dodecyl-5-methylphenol (1115234-57-5) + C31H56O (1115234-61-1)

Guidance literature:

With Ni(1,2-bis(diphenylphosphanyl)-benzene)Cl₂; In toluene; at 0 - 20 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1021/ol802824b

upstream raw materials:

2-chloro-5-methylphenol

Downstream raw materials:

1-bromo-5-chloro-4-methoxy-2-methylbenzene

(3-chloro-4-methoxy-6-methylphenyl)boronic acid

5'-[2-(5-chloro-4'-hydroxymethyl-4,2'-dimethoxy-biphenyl-2-yl)-ethyl]-6,2'-dimethoxy-biphenyl-3-carbaldehyde

5-chloro-5'-[2-(5-chloro-4'-hydroxymethyl-4,2'-dimethoxy-biphenyl-2-yl)-ethyl]-6,2'-dimethoxy-biphenyl-3-carbaldehyde

Refernces

• 1、 Hajipour, Abdol R.,Pourmousavi, Seied A.,Ruoho, Arnold E.. "1-Benzyl-4-aza-1-azoniabicyclo[2.2.2]octane tribromide as a regenerable and useful reagent for bromination of phenols under mild conditions". . p. 796 - 800. Retrieved 2007/10/03.
• 2、 Speicher, Andreas,Kolz, Juergen,Sambanje, Rufino Paulino. "Syntheses of chlorinated bisbibenzyls from bryophytes". . p. 2503 - 2512. Retrieved 2007/10/03.