N-[4-(2-{2-[2-(2-{2-[4-(3,5-dioxo-hexyl)-phenylcarbamoyl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-2'-(isoxazol-5-ylsulfamoyl)-biphenyl-2-ylmethyl]-3,3,N-trimethyl-butyramide

Base Information

Chemical Name:N-[4-(2-{2-[2-(2-{2-[4-(3,5-dioxo-hexyl)-phenylcarbamoyl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-2'-(isoxazol-5-ylsulfamoyl)-biphenyl-2-ylmethyl]-3,3,N-trimethyl-butyramide
CAS No.:929087-81-0
Molecular Formula:C₄₆H₆₀N₄O₁₂S
Molecular Weight:893.068
Hs Code.:

<i>N</i>-[4-(2-{2-[2-(2-{2-[4-(3,5-dioxo-hexyl)-phenylcarbamoyl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-2'-(isoxazol-5-ylsulfamoyl)-biphenyl-2-ylmethyl]-3,3,<i>N</i>-trimethyl-butyramide

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Chemical Property of N-[4-(2-{2-[2-(2-{2-[4-(3,5-dioxo-hexyl)-phenylcarbamoyl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-2'-(isoxazol-5-ylsulfamoyl)-biphenyl-2-ylmethyl]-3,3,N-trimethyl-butyramide

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Technology Process of N-[4-(2-{2-[2-(2-{2-[4-(3,5-dioxo-hexyl)-phenylcarbamoyl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-2'-(isoxazol-5-ylsulfamoyl)-biphenyl-2-ylmethyl]-3,3,N-trimethyl-butyramide

There total 14 articles about N-[4-(2-{2-[2-(2-{2-[4-(3,5-dioxo-hexyl)-phenylcarbamoyl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-2'-(isoxazol-5-ylsulfamoyl)-biphenyl-2-ylmethyl]-3,3,N-trimethyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 929087-93-4
N-(2'-(isoxazol-5-ylsulfamoyl)-4-{2-[2-(2-{2-[2-(4-{2-[2-(2-methyl-[1,3]dioxolan-2-ylmethyl)-[1,3]dioxolan-2-yl]-ethyl}-phenylcarbamoyl)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-biphenyl-2-ylmethyl)-3,3,N-trimethyl-butyramide

: 929087-81-0
N-[4-(2-{2-[2-(2-{2-[4-(3,5-dioxo-hexyl)-phenylcarbamoyl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-2'-(isoxazol-5-ylsulfamoyl)-biphenyl-2-ylmethyl]-3,3,N-trimethyl-butyramide

Guidance literature:: With toluene-4-sulfonic acid; acetone;
DOI:10.1016/j.bmcl.2006.10.009

Reference yield:

: 192650-25-2
6-(4-nitrophenyl)hexane-2,4-dione

: 929087-81-0
N-[4-(2-{2-[2-(2-{2-[4-(3,5-dioxo-hexyl)-phenylcarbamoyl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-2'-(isoxazol-5-ylsulfamoyl)-biphenyl-2-ylmethyl]-3,3,N-trimethyl-butyramide

Guidance literature:: Multi-step reaction with 6 steps

1: 65 percent / pTSA / toluene / Heating

2: 95 percent / H₂ / Pd/C / ethyl acetate

3: EDCI / CH₂Cl₂

4: NaH(OAc)3

5: DIEA / CH₂Cl₂ / -5 °C

6: 82 percent / p-TSA; acetone

With NaH(OAc)3; hydrogen; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; acetone; palladium on activated charcoal; In dichloromethane; ethyl acetate; toluene;
DOI:10.1016/j.bmcl.2006.10.009

Reference yield:

: 782475-33-6
C₁₆H₂₁NO₆

: 929087-81-0
N-[4-(2-{2-[2-(2-{2-[4-(3,5-dioxo-hexyl)-phenylcarbamoyl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-2'-(isoxazol-5-ylsulfamoyl)-biphenyl-2-ylmethyl]-3,3,N-trimethyl-butyramide

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / H₂ / Pd/C / ethyl acetate

2: EDCI / CH₂Cl₂

3: NaH(OAc)3

4: DIEA / CH₂Cl₂ / -5 °C

5: 82 percent / p-TSA; acetone

With NaH(OAc)3; hydrogen; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; acetone; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2006.10.009