Cbz-Lys(Cbz)-^DAla-^Dp-(methyl)histidine-ONBu₄

Base Information

• Chemical Name: Cbz-Lys(Cbz)-^DAla-^Dp-(methyl)histidine-ONBu₄
• CAS No.: 1378999-80-4
• Molecular Formula: C₁₆H₃₆N*C₃₂H₃₉N₆O₈
• Molecular Weight: 878.166
• Mol file: 1378999-80-4.mol

Synonyms:

Chemical Property of Cbz-Lys(Cbz)-^DAla-^Dp-(methyl)histidine-ONBu₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cbz-Lys(Cbz)-^DAla-^Dp-(methyl)histidine-ONBu₄

There total 3 articles about Cbz-Lys(Cbz)-^DAla-^Dp-(methyl)histidine-ONBu₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N'-di-[(phenylmethoxy)carbonyl]-L-lysine (405-39-0) → Cbz-Lys(Cbz)-DAla-Dp-(methyl)histidine-ONBu4 (1378999-80-4)

Guidance literature:

Multi-step reaction with 4 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

2: sodium hydroxide / water; methanol / 15 h / 20 °C

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

4: water; methanol / 3 h / 20 °C

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane; water;

DOI:10.1021/jm501872s

Reference yield:

C26H33N3O7 (1378999-76-8) → Cbz-Lys(Cbz)-DAla-Dp-(methyl)histidine-ONBu4 (1378999-80-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / water; methanol / 15 h / 20 °C

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

3: water; methanol / 3 h / 20 °C

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane; water;

DOI:10.1021/jm501872s

Reference yield:

Cbz-Lys(Cbz)-DAla-Dp-(methyl)histidine-OMe + tetra(n-butyl)ammonium hydroxide (2052-49-5) → Cbz-Lys(Cbz)-DAla-Dp-(methyl)histidine-ONBu4 (1378999-80-4)

Guidance literature:

In methanol; water; at 20 ℃; for 3h;

DOI:10.1021/jm501872s

upstream raw materials:

tetra(n-butyl)ammonium hydroxide

N,N'-di-[(phenylmethoxy)carbonyl]-L-lysine

C₂₆H₃₃N₃O₇