o-methyl-p-tritylphenylacetylene

Base Information

• Chemical Name: o-methyl-p-tritylphenylacetylene
• CAS No.: 444278-89-1
• Molecular Formula: C₂₈H₂₂
• Molecular Weight: 358.483
• Mol file: 444278-89-1.mol

Synonyms:

Chemical Property of o-methyl-p-tritylphenylacetylene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of o-methyl-p-tritylphenylacetylene

There total 3 articles about o-methyl-p-tritylphenylacetylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-methyl-4-(2-methyl-4-trityl-phenyl)-but-3-yn-2-ol (444278-91-5) → o-methyl-p-tritylphenylacetylene (444278-89-1)

Guidance literature:

With sodium hydroxide; In isopropyl alcohol; toluene; Heating;

Reference yield:

2-methyl-4-trityl-aniline (101984-94-5) → o-methyl-p-tritylphenylacetylene (444278-89-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: AcOH; NaNO₂; H₂SO₄ / 0 °C

1.2: 56 percent / KI; I₂ / 20 °C

2.1: 77 percent / CuI; Et₃N / 5 percent Pd(PPh₃)2Cl₂ / dimethylformamide / 80 °C

3.1: 71 percent / NaOH / toluene; propan-2-ol / Heating

With sodium hydroxide; copper(l) iodide; sulfuric acid; acetic acid; triethylamine; sodium nitrite; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; isopropyl alcohol; toluene; 1.2: Sandmeyer reaction / 2.1: Sonogashira reaction;

Reference yield:

1-Iodo-2-methyl-4-trityl-benzene (444278-93-7) → o-methyl-p-tritylphenylacetylene (444278-89-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / CuI; Et₃N / 5 percent Pd(PPh₃)2Cl₂ / dimethylformamide / 80 °C

2: 71 percent / NaOH / toluene; propan-2-ol / Heating

With sodium hydroxide; copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; isopropyl alcohol; toluene; 1: Sonogashira reaction;

upstream raw materials:

2-methyl-4-(2-methyl-4-trityl-phenyl)-but-3-yn-2-ol

2-methyl-4-trityl-aniline

1-Iodo-2-methyl-4-trityl-benzene