Benzyl-[(S)-2-(dimethyl-phenyl-silanyl)-1-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-ethyl]-carbamic acid benzyl ester

Base Information

• Chemical Name: Benzyl-[(S)-2-(dimethyl-phenyl-silanyl)-1-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-ethyl]-carbamic acid benzyl ester
• CAS No.: 161377-17-9
• Molecular Formula: C₃₆H₄₅NO₇Si
• Molecular Weight: 631.841
• Mol file: 161377-17-9.mol

Synonyms:

Chemical Property of Benzyl-[(S)-2-(dimethyl-phenyl-silanyl)-1-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-ethyl]-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzyl-[(S)-2-(dimethyl-phenyl-silanyl)-1-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-ethyl]-carbamic acid benzyl ester

There total 3 articles about Benzyl-[(S)-2-(dimethyl-phenyl-silanyl)-1-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-ethyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(dimethylphenylsilyl)methyl]magnesium chloride (107735-20-6) → Benzyl-[(S)-2-(dimethyl-phenyl-silanyl)-1-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-ethyl]-carbamic acid benzyl ester (161377-17-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) CuI, 2.) BF₃*Et₂O / 1.) - 40 deg C, 2.) -78 deg C

2: NaHCO₃

With copper(l) iodide; boron trifluoride diethyl etherate; sodium hydrogencarbonate;

DOI:10.1016/S0957-4166(00)86303-X

Reference yield:

Benzyl-[1-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-meth-(E)-ylidene]-amine → Benzyl-[(S)-2-(dimethyl-phenyl-silanyl)-1-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-ethyl]-carbamic acid benzyl ester (161377-17-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) CuI, 2.) BF₃*Et₂O / 1.) - 40 deg C, 2.) -78 deg C

2: NaHCO₃

With copper(l) iodide; boron trifluoride diethyl etherate; sodium hydrogencarbonate;

DOI:10.1016/S0957-4166(00)86303-X

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + Benzyl-[(S)-2-(dimethyl-phenyl-silanyl)-1-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-ethyl]-amine (161377-16-8) → Benzyl-[(S)-2-(dimethyl-phenyl-silanyl)-1-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-ethyl]-carbamic acid benzyl ester (161377-17-9)

Guidance literature:

With sodium hydrogencarbonate;

DOI:10.1016/S0957-4166(00)86303-X

upstream raw materials:

benzyl chloroformate

Benzyl-[(S)-2-(dimethyl-phenyl-silanyl)-1-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-ethyl]-amine

[(dimethylphenylsilyl)methyl]magnesium chloride

Downstream raw materials:

Benzyl-[(R)-2-hydroxy-1-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-ethyl]-carbamic acid benzyl ester