cis-N-(Diphenylphosphinyl)-2-methylcyclohexylamine

Base Information

• Chemical Name: cis-N-(Diphenylphosphinyl)-2-methylcyclohexylamine
• CAS No.: 115668-09-2
• Molecular Formula: C₁₉H₂₄NOP
• Molecular Weight: 313.379
• Mol file: 115668-09-2.mol

Synonyms:

Chemical Property of cis-N-(Diphenylphosphinyl)-2-methylcyclohexylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-N-(Diphenylphosphinyl)-2-methylcyclohexylamine

There total 14 articles about cis-N-(Diphenylphosphinyl)-2-methylcyclohexylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

C19H22NOP (172847-52-8) → cis-N-(Diphenylphosphinyl)-2-methylcyclohexylamine (115668-09-2,115685-79-5)

Guidance literature:

With L-Selectride; In tetrahydrofuran; Ambient temperature;

DOI:10.1016/S0040-4039(00)96795-9

Reference yield: 64.0%

C19H22NOP → cis-N-(Diphenylphosphinyl)-2-methylcyclohexylamine (115668-09-2,115685-79-5)

Guidance literature:

With L-Selectride; In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1021/jo00128a009

Reference yield:

2-methylcyclohexanone anti-oxime (32179-89-8) → cis-N-(Diphenylphosphinyl)-2-methylcyclohexylamine (115668-09-2,115685-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂; petroleum ether / 2 h / -50 °C

2: (tert-butylamino)borane / methanol / Ambient temperature

With 1,1-dimethylethylaminoborane; triethylamine; In methanol; dichloromethane; Petroleum ether;

DOI:10.1021/jo00128a009

upstream raw materials:

C₁₉H₂₂NOP

2-methylcyclohexanone anti-oxime

2-Methylcyclohexanone

2-methylcyclohexanone oxime

Refernces

• 1、 Hutchins, Robert O.,Rutledge, Melvin C.. "HIGHLY DIASTEREOSELECTIVE REDUCTIONS OF N-DIPHENYLPHOSPHINYL IMINES. SYNTHESIS OF AXIAL PRIMARY CYCLIC AMINES.". . p. 5619 - 5622. Retrieved 2007/10/02.