Technology Process of Ethanone,
1-[2-[2-(1,3-dioxolan-2-yl)ethyl]-1-(phenylmethyl)-2-piperidinyl]-, (R)-
There total 8 articles about Ethanone,
1-[2-[2-(1,3-dioxolan-2-yl)ethyl]-1-(phenylmethyl)-2-piperidinyl]-, (R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 94 percent / LDA / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C
2: diethyl ether / 1) 1 h, -78 deg C 2) 2 h, 0 deg C
3: H2O2, citric acid / CH2Cl2 / 48 h / pH 2-3
4: 100 percent / LiAlH4, AlCl3 / tetrahydrofuran / -40 °C
5: H2 / Pd/C / methanol
6: NaHCO3 / dimethylformamide / 2 h / 80 °C
7: 1) (COCl)2, DMSO 2) Et3N
With
lithium aluminium tetrahydride; aluminium trichloride; oxalyl dichloride; hydrogen; dihydrogen peroxide; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; citric acid; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)74361-9
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 94 percent / LDA / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C
2: diethyl ether / 1) 1 h, -78 deg C 2) 2 h, 0 deg C
3: H2O2, citric acid / CH2Cl2 / 48 h / pH 2-3
4: 100 percent / LiAlH4, AlCl3 / tetrahydrofuran / -40 °C
5: H2 / Pd/C / methanol
6: NaHCO3 / dimethylformamide / 2 h / 80 °C
7: 1) (COCl)2, DMSO 2) Et3N
With
lithium aluminium tetrahydride; aluminium trichloride; oxalyl dichloride; hydrogen; dihydrogen peroxide; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; citric acid; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)74361-9
- Guidance literature:
-
Multi-step reaction with 3 steps
1: H2 / Pd/C / methanol
2: NaHCO3 / dimethylformamide / 2 h / 80 °C
3: 1) (COCl)2, DMSO 2) Et3N
With
oxalyl dichloride; hydrogen; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine;
palladium on activated charcoal;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)74361-9
