L-Histidine, N-[(1,1-dimethylethoxy)carbonyl]-3-(2,4-dinitrophenyl)-

Base Information

• Chemical Name: L-Histidine, N-[(1,1-dimethylethoxy)carbonyl]-3-(2,4-dinitrophenyl)-
• CAS No.: 135409-37-9
• Molecular Formula: C17H19N5O8
• Molecular Weight: 421.36100
• Mol file: 135409-37-9.mol

Synonyms:Nα-tert-butoxycarbonyl-3-(2,4-dinitro-phenyl)-histidine;(S)-2-tert-Butoxycarbonylamino-3-[3-(2,4-dinitro-phenyl)-3H-imidazol-4-yl]-propionic acid;

Chemical Property of L-Histidine, N-[(1,1-dimethylethoxy)carbonyl]-3-(2,4-dinitrophenyl)-

Chemical Property:

• Boiling Point: 663.2±55.0 °C(Predicted)
• PSA: 185.09000
• Density: 1.49±0.1 g/cm3(Predicted)
• LogP: 3.64640

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Histidine, N-[(1,1-dimethylethoxy)carbonyl]-3-(2,4-dinitrophenyl)-

There total 1 articles about L-Histidine, N-[(1,1-dimethylethoxy)carbonyl]-3-(2,4-dinitrophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Boc-L-His(Dnp)-OH (135409-37-9)

Guidance literature:

DOI:10.1002/hlca.19710540139

Reference yield: 97.0%

SQ 10018 (2804-16-2) + Boc-L-His(Dnp)-OH (135409-37-9) → ((S)-1-[3-(2,4-Dinitro-phenyl)-3H-imidazol-4-ylmethyl]-2-oxo-2-{4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethyl)-carbamic acid tert-butyl ester (140868-61-7)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)91569-7

Reference yield: 86.0%

1-octadecanol (112-92-5) + Boc-L-His(Dnp)-OH (135409-37-9) → octadecyl ester of Nα-tert-butoxycarbonyl-Nim-dinitrophenyl-L-histidine

Guidance literature:

With pyridine; dmap; di-tert-butyl dicarbonate; In chloroform; at 20 ℃; for 4h;

Downstream raw materials:

((S)-1-[3-(2,4-Dinitro-phenyl)-3H-imidazol-4-ylmethyl]-2-oxo-2-{4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethyl)-carbamic acid tert-butyl ester

{(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-[3-(2,4-dinitro-phenyl)-3H-imidazol-4-yl]-ethyl}-carbamic acid tert-butyl ester

(S)-2-Amino-3-[3-(2,4-dinitro-phenyl)-3H-imidazol-4-yl]-1-{4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-propan-1-one

({[((S)-1-[3-(2,4-Dinitro-phenyl)-3H-imidazol-4-ylmethyl]-2-oxo-2-{4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethylcarbamoyl)-methyl]-carbamoyl}-methyl)-carbamic acid tert-butyl ester

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