Piperazine, 1-[2-amino-3-[1-(2,4-dinitrophenyl)-1H-imidazol-5-yl]-1-oxopropyl]-4-[3-[ 2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-, (S)-

Base Information

• Chemical Name: Piperazine, 1-[2-amino-3-[1-(2,4-dinitrophenyl)-1H-imidazol-5-yl]-1-oxopropyl]-4-[3-[ 2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-, (S)-
• CAS No.: 140868-62-8
• Molecular Formula: C32H31F3N8O5S
• Molecular Weight: 696.71
• Mol file: 140868-62-8.mol

Synonyms:

Chemical Property of Piperazine, 1-[2-amino-3-[1-(2,4-dinitrophenyl)-1H-imidazol-5-yl]-1-oxopropyl]-4-[3-[ 2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-, (S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Piperazine, 1-[2-amino-3-[1-(2,4-dinitrophenyl)-1H-imidazol-5-yl]-1-oxopropyl]-4-[3-[ 2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-, (S)-

There total 3 articles about Piperazine, 1-[2-amino-3-[1-(2,4-dinitrophenyl)-1H-imidazol-5-yl]-1-oxopropyl]-4-[3-[ 2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

((S)-1-[3-(2,4-Dinitro-phenyl)-3H-imidazol-4-ylmethyl]-2-oxo-2-{4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethyl)-carbamic acid tert-butyl ester (140868-61-7) → (S)-2-Amino-3-[3-(2,4-dinitro-phenyl)-3H-imidazol-4-yl]-1-{4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-propan-1-one (140868-62-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0040-4039(00)91569-7

Reference yield:

SQ 10018 (2804-16-2) → (S)-2-Amino-3-[3-(2,4-dinitro-phenyl)-3H-imidazol-4-yl]-1-{4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-propan-1-one (140868-62-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / EDCI / tetrahydrofuran

2: 83 percent / CF₃CO₂H / CH₂Cl₂

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(00)91569-7

Reference yield:

Boc-L-His(Dnp)-OH (135409-37-9) → (S)-2-Amino-3-[3-(2,4-dinitro-phenyl)-3H-imidazol-4-yl]-1-{4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-propan-1-one (140868-62-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / EDCI / tetrahydrofuran

2: 83 percent / CF₃CO₂H / CH₂Cl₂

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(00)91569-7

upstream raw materials:

((S)-1-[3-(2,4-Dinitro-phenyl)-3H-imidazol-4-ylmethyl]-2-oxo-2-{4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethyl)-carbamic acid tert-butyl ester

SQ 10018

Boc-L-His(Dnp)-OH

Downstream raw materials:

({[((S)-1-[3-(2,4-Dinitro-phenyl)-3H-imidazol-4-ylmethyl]-2-oxo-2-{4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethylcarbamoyl)-methyl]-carbamoyl}-methyl)-carbamic acid tert-butyl ester