(S)-3-(tert-butyl)-9a-(2-phenoxyethyl)-8,9,9a,10-tetrahydrofluoreno[1,2-d][1,2,3]triazol-7(3H)-one

Base Information

Chemical Name:(S)-3-(tert-butyl)-9a-(2-phenoxyethyl)-8,9,9a,10-tetrahydrofluoreno[1,2-d][1,2,3]triazol-7(3H)-one
CAS No.:1398510-92-3
Molecular Formula:C₂₅H₂₇N₃O₂
Molecular Weight:401.508
Hs Code.:

Synonyms:

Suppliers and Price of (S)-3-(tert-butyl)-9a-(2-phenoxyethyl)-8,9,9a,10-tetrahydrofluoreno[1,2-d][1,2,3]triazol-7(3H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (S)-3-(tert-butyl)-9a-(2-phenoxyethyl)-8,9,9a,10-tetrahydrofluoreno[1,2-d][1,2,3]triazol-7(3H)-one

Chemical Property:

Purity/Quality:: ≥95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-3-(tert-butyl)-9a-(2-phenoxyethyl)-8,9,9a,10-tetrahydrofluoreno[1,2-d][1,2,3]triazol-7(3H)-one

There total 15 articles about (S)-3-(tert-butyl)-9a-(2-phenoxyethyl)-8,9,9a,10-tetrahydrofluoreno[1,2-d][1,2,3]triazol-7(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 141482-06-6
1-methanesulfonyloxy-2-(phenoxy)ethane

: 1398510-92-3
(S)-3-(tert-butyl)-9a-(2-phenoxyethyl)-8,9,9a,10-tetrahydrofluoreno[1,2-d][1,2,3]triazol-7(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium iodide / Inert atmosphere

2.1: lithium hexamethyldisilazane; 1,4-diaza-bicyclo[2.2.2]octane / methanol; tetrahydrofuran / 10 - 30 °C / Inert atmosphere; Large scale

3.1: lithium hexamethyldisilazane / tetrahydrofuran / Inert atmosphere; Cooling; Large scale

4.1: n-hexyllithium / tetrahydrofuran; toluene; hexane / 0.92 h / -57 - -15 °C / Inert atmosphere; Large scale

4.2: 20 °C / Inert atmosphere; Large scale

5.1: acetic acid; piperidine / toluene / Dean-Stark; Heating; Large scale

With piperidine; 1,4-diaza-bicyclo[2.2.2]octane; n-hexyllithium; acetic acid; sodium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; hexane; toluene;
DOI:10.1021/op5000489

Reference yield:

: 1135351-95-9
4-bromo-N-(tert-butyl)-2-nitroaniline

: 1398510-92-3
(S)-3-(tert-butyl)-9a-(2-phenoxyethyl)-8,9,9a,10-tetrahydrofluoreno[1,2-d][1,2,3]triazol-7(3H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen; toluene-4-sulfonic acid; / methanol / 4 h / 15 - 25 °C / 3750.38 Torr / Inert atmosphere; Large scale

2.1: hydrogenchloride / water / 0.08 h / Inert atmosphere; Large scale

2.2: 0 - 10 °C / Large scale

3.1: n-hexyllithium; tert-butylmagnesium chloride; 2,2,6,6-tetramethyl-piperidine / tetrahydrofuran; hexane / 3.42 h / -45 - -10 °C / Inert atmosphere; Large scale

3.2: Inert atmosphere; Large scale

4.1: sodium tetrahydroborate / ethanol / -30 - -20 °C / Inert atmosphere; Large scale

5.1: phosphorus tribromide / tetrahydrofuran / 0 - 5 °C / Inert atmosphere; Large scale

6.1: lithium hexamethyldisilazane / tetrahydrofuran / Inert atmosphere; Cooling; Large scale

7.1: n-hexyllithium / tetrahydrofuran; toluene; hexane / 0.92 h / -57 - -15 °C / Inert atmosphere; Large scale

7.2: 20 °C / Inert atmosphere; Large scale

8.1: acetic acid; piperidine / toluene / Dean-Stark; Heating; Large scale

With piperidine; 2,2,6,6-tetramethyl-piperidine; hydrogenchloride; sodium tetrahydroborate; tert-butylmagnesium chloride; hydrogen; n-hexyllithium; phosphorus tribromide; toluene-4-sulfonic acid; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; hexane; water; toluene;
DOI:10.1021/op5000489

Reference yield:

: 1579951-61-3
5-bromo-1-(tert-butyl)-1H-benzo[d][1,2,3]triazole

: 1398510-92-3
(S)-3-(tert-butyl)-9a-(2-phenoxyethyl)-8,9,9a,10-tetrahydrofluoreno[1,2-d][1,2,3]triazol-7(3H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-hexyllithium; tert-butylmagnesium chloride; 2,2,6,6-tetramethyl-piperidine / tetrahydrofuran; hexane / 3.42 h / -45 - -10 °C / Inert atmosphere; Large scale

1.2: Inert atmosphere; Large scale

2.1: sodium tetrahydroborate / ethanol / -30 - -20 °C / Inert atmosphere; Large scale

3.1: phosphorus tribromide / tetrahydrofuran / 0 - 5 °C / Inert atmosphere; Large scale

4.1: lithium hexamethyldisilazane / tetrahydrofuran / Inert atmosphere; Cooling; Large scale

5.1: n-hexyllithium / tetrahydrofuran; toluene; hexane / 0.92 h / -57 - -15 °C / Inert atmosphere; Large scale

5.2: 20 °C / Inert atmosphere; Large scale

6.1: acetic acid; piperidine / toluene / Dean-Stark; Heating; Large scale

With piperidine; 2,2,6,6-tetramethyl-piperidine; sodium tetrahydroborate; tert-butylmagnesium chloride; n-hexyllithium; phosphorus tribromide; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; hexane; toluene;
DOI:10.1021/op5000489