Chemical Property of 2-Phenoxyethanol
Chemical Property:
- Appearance/Colour:colorless or light yellow liquid
- Vapor Pressure:0.01 mm Hg ( 20 °C)
- Melting Point:11-13 °C
- Refractive Index:1.5386
- Boiling Point:245.199 °C at 760 mmHg
- PKA:14.36±0.10(Predicted)
- Flash Point:105.275 °C
- PSA：29.46000
- Density:1.102 g/cm3
- LogP:1.05770
- Storage Temp.:room temp
- Solubility.:soluble, clear, colorless to very faintly yellow
- Water Solubility.:30 g/L (20 ºC)
- XLogP3:1.2
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:3
- Exact Mass:138.068079557
- Heavy Atom Count:10
- Complexity:77.3
- Purity/Quality:
-
99% *data from raw suppliers
2-Phenoxyethanol 97% *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn,
Xi
- Hazard Codes:Xn,Xi
- Statements:
22-36-R36-R22
- Safety Statements:
26-S26
- MSDS Files:
-
SDS file from LookChem
Useful:
- Chemical Classes:Solvents -> Glycol Ethers (E Series)
- Canonical SMILES:C1=CC=C(C=C1)OCCO
- Recent EU Clinical Trials:An open-label, controlled, randomized, prospective, between groups, multicenter clinical trial on the efficacy and safety of Fitostimoline (vaginal cream, vaginal suppositories and vaginal solution) and of Tantum Rosa (vaginal cream and vaginal solution) in the treatment of the vaginosis (non specific vaginitis)
- Inhalation Risk:A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C.
- Effects of Short Term Exposure:The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system and peripheral nervous system. This may result in impaired functions.
- Effects of Long Term Exposure:The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the central nervous system. This may result in impaired functions.
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Description
Phenoxyethanol is an organic chemical compound, a glycol ether often used in dermatological products such as skin creams and sunscreen. It is a colorless oily liquid. It is a bactericide (usually used in conjunction with quaternary ammonium compounds). Phenoxyethanol is used in many applications such as cosmetics, vaccines and pharmaceuticals as a preservative.
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Uses
phenoxyethanol is a broad-range preservative with fungicidal, bactericidal, insecticidal, and germicidal properties. It has a relatively low sensitizing factor in leave-on cosmetics. Phenoxyethanol can be used in concentrations of 0.5 to 2.0 percent, and in combination with other preservatives such as sorbic acid or parabens. In addition, it is used as a solvent for aftershaves, face and hair lotions, shampoos, and skin creams of all types. It can be obtained from phenol. Ethylene glycol phenyl ether at a
1.0% level acts as a preservative in personal care products. Phenoxyethanol is a preservative used in consumer and health care products, including vaccines, pen inks, ear drops, shampoos, skin cleansers, moisturizers, sun care products, and topical medicaments. The preservative Euxyl-K 400 also contains 2-phenoxyethanol, in combination with methyldibromoglutaronitrile.
Phenoxyethanol is commonly used in cosmetics for its antibacterial and antifungal properties. It is increasingly being used in vaccines as a substitute for thiomersal and is also a component of pen inks and, more rarely, ear drops.Reactions to phenoxyethanol have rarely been reported. Three cases of CoU induced by phenoxyethanol in cosmetics have been reported.2-Phenoxyethanol is used as a single agent and in combination with other preservatives such as 1,2-dibromo-2,4-dicyanobutane (Euxyl K 400) and parabens, or in conjunction with quaternary ammonium compounds.The possibility of immunological IgE-mediated reaction could not be confirmed because specific IgE against 2-phenoxyethanol was negative. Antimicrobial preservative; also used topically in treatment of bacterial infections.
