(R)-N²-Methyl-3-[(R)-2-methylamino-3-((R)-1-phenyl-ethylamino)-propyldisulfanyl]-N¹-((R)-1-phenyl-ethyl)-propane-1,2-diamine

Base Information

• Chemical Name: (R)-N²-Methyl-3-[(R)-2-methylamino-3-((R)-1-phenyl-ethylamino)-propyldisulfanyl]-N¹-((R)-1-phenyl-ethyl)-propane-1,2-diamine
• CAS No.: 448927-81-9
• Molecular Formula: C₂₄H₃₈N₄S₂
• Molecular Weight: 446.725
• Mol file: 448927-81-9.mol

Synonyms:

Chemical Property of (R)-N²-Methyl-3-[(R)-2-methylamino-3-((R)-1-phenyl-ethylamino)-propyldisulfanyl]-N¹-((R)-1-phenyl-ethyl)-propane-1,2-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N²-Methyl-3-[(R)-2-methylamino-3-((R)-1-phenyl-ethylamino)-propyldisulfanyl]-N¹-((R)-1-phenyl-ethyl)-propane-1,2-diamine

There total 3 articles about (R)-N²-Methyl-3-[(R)-2-methylamino-3-((R)-1-phenyl-ethylamino)-propyldisulfanyl]-N¹-((R)-1-phenyl-ethyl)-propane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(R)-2-[(R)-2-Ethoxycarbonylamino-2-((R)-1-phenyl-ethylcarbamoyl)-ethyldisulfanyl]-1-((R)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid ethyl ester (448927-71-7) → (R)-N2-Methyl-3-[(R)-2-methylamino-3-((R)-1-phenyl-ethylamino)-propyldisulfanyl]-N1-((R)-1-phenyl-ethyl)-propane-1,2-diamine (448927-81-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

DOI:10.1016/S0040-4039(02)00300-3

Reference yield:

(R,R)-N,N'-diethoxycarbonyl-3,3'-dithiobis(2-aminopropionic acid) (19887-39-9) → (R)-N2-Methyl-3-[(R)-2-methylamino-3-((R)-1-phenyl-ethylamino)-propyldisulfanyl]-N1-((R)-1-phenyl-ethyl)-propane-1,2-diamine (448927-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-methylmorpholine / CHCl₃

1.2: ethyl chloroformate

2.1: LiAlH₄ / tetrahydrofuran / Heating

With 4-methyl-morpholine; lithium aluminium tetrahydride; In tetrahydrofuran; chloroform;

DOI:10.1016/S0040-4039(02)00300-3

Reference yield:

L-cystine (56-89-3) → (R)-N2-Methyl-3-[(R)-2-methylamino-3-((R)-1-phenyl-ethylamino)-propyldisulfanyl]-N1-((R)-1-phenyl-ethyl)-propane-1,2-diamine (448927-81-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 98 percent / aq. NaOH

2.1: N-methylmorpholine / CHCl₃

2.2: ethyl chloroformate

3.1: LiAlH₄ / tetrahydrofuran / Heating

With 4-methyl-morpholine; sodium hydroxide; lithium aluminium tetrahydride; In tetrahydrofuran; chloroform;

DOI:10.1016/S0040-4039(02)00300-3

upstream raw materials:

[(R)-2-[(R)-2-Ethoxycarbonylamino-2-((R)-1-phenyl-ethylcarbamoyl)-ethyldisulfanyl]-1-((R)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid ethyl ester

(R,R)-N,N'-diethoxycarbonyl-3,3'-dithiobis(2-aminopropionic acid)

L-cystine