N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[3-(2-morpholin-4-yl-ethyl)-2,4,8-trioxo-6-phenyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl]-acetamide

Base Information

Chemical Name:N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[3-(2-morpholin-4-yl-ethyl)-2,4,8-trioxo-6-phenyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl]-acetamide
CAS No.:1025912-47-3
Molecular Formula:C₃₃H₄₆F₃N₅O₆Si
Molecular Weight:693.839
Hs Code.:

N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[3-(2-morpholin-4-yl-ethyl)-2,4,8-trioxo-6-phenyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl]-acetamide

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Chemical Property of N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[3-(2-morpholin-4-yl-ethyl)-2,4,8-trioxo-6-phenyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl]-acetamide

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Technology Process of N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[3-(2-morpholin-4-yl-ethyl)-2,4,8-trioxo-6-phenyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl]-acetamide

There total 13 articles about N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[3-(2-morpholin-4-yl-ethyl)-2,4,8-trioxo-6-phenyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026744-80-8
[1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-4-(2-morpholin-4-yl-ethylcarbamoyl)-2-oxo-6-phenyl-1,2-dihydro-pyridin-3-yl]-carbamic acid benzyl ester

: 1025912-47-3
N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[3-(2-morpholin-4-yl-ethyl)-2,4,8-trioxo-6-phenyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl]-acetamide

Guidance literature:: In N,N-dimethyl-formamide; at 120 ℃; for 16h; Yield given;
DOI:10.1021/jm950684z

Reference yield:

: 106746-09-2
3(RS)-amino-1,1,1-trifluoro-2(RS)-hydroxy-4-methylpentane hydrochloride

: 1025912-47-3
N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[3-(2-morpholin-4-yl-ethyl)-2,4,8-trioxo-6-phenyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl]-acetamide

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) NMM, isobutyl chloroformate / 1.) THF, from -40 deg C to -20 deg C, 1.5 h, 2.) THF, RT, 1.5 h

2: 2,6-lutidine / tetrahydrofuran / 16 h / Ambient temperature

3: 81 percent / N₂H₄*H₂O / 3 h / Heating

4: 48 percent / 24 h / 120 °C / 1 Torr

5: 96 percent / LiI / pyridine / 14 h / Heating

6: 84 percent / diphenyl phosphoroazidate, TEA / dioxane / 4 h / Heating

7: 53 percent / aq. LiOH*H₂O / ethanol / 7 h / 0 °C

8: 1.) isobutyl chloroformate, NMM / 1.) THF, from -40 deg C to -30 deg C, 1 h, 2.) THF, RT, 16 h

9: dimethylformamide / 16 h / 120 °C

With 4-methyl-morpholine; 2,6-dimethylpyridine; lithium hydroxide; TEA; diphenyl phosphoryl azide; hydrazine hydrate; lithium iodide; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; pyridine; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm950684z

Reference yield:

: 2397-26-4
N,N-dimethyl(chlorophenylmethylene)ammonium chloride

: 1025912-47-3
N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[3-(2-morpholin-4-yl-ethyl)-2,4,8-trioxo-6-phenyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl]-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NaH / 1.) THF, hexane, RT, 4.5 h, 2.) THF, hexane, RT, 1 h

2: 48 percent / 24 h / 120 °C / 1 Torr

3: 96 percent / LiI / pyridine / 14 h / Heating

4: 84 percent / diphenyl phosphoroazidate, TEA / dioxane / 4 h / Heating

5: 53 percent / aq. LiOH*H₂O / ethanol / 7 h / 0 °C

6: 1.) isobutyl chloroformate, NMM / 1.) THF, from -40 deg C to -30 deg C, 1 h, 2.) THF, RT, 16 h

7: dimethylformamide / 16 h / 120 °C

With 4-methyl-morpholine; lithium hydroxide; TEA; diphenyl phosphoryl azide; sodium hydride; lithium iodide; isobutyl chloroformate; In 1,4-dioxane; pyridine; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm950684z