Rosuvastatin Anhydro Lactone

Base Information

• Chemical Name: Rosuvastatin Anhydro Lactone
• CAS No.: 1246665-85-9
• Molecular Formula: C₂₂H₂₄FN₃O₄S
• Molecular Weight: 445.515
• Mol file: 1246665-85-9.mol

Synonyms:

Chemical Property of Rosuvastatin Anhydro Lactone

Chemical Property:

Purity/Quality:

> 95% ^*data from raw suppliers

RosuvastatinAnhydroLactone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Rosuvastatin Anhydro Lactone, is an intermediate in the production of Rosuvastatin (R700500) derivatives.

Technology Process of Rosuvastatin Anhydro Lactone

There total 2 articles about Rosuvastatin Anhydro Lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(5-((E)-2-((2S,4R)-4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide + C28H45FN3O2PS (1246665-81-5) → N-(4-(4-fluorophenyl)-6-isopropyl-5-methylpyrimidin-2-yl)-N-methylmethanesulfonamide (953776-62-0) + (S,E)-N-(4-(4-fluorophenyl)-6-isopropyl-5-(2-(6-oxo-3,6-dihydro-2H-pyran-2-yl)vinyl)pyrimidin-2-yl)-N-methylmethanesulfonamide (1246665-85-9)

Guidance literature:

In toluene; at 20 ℃; for 0.25h;

DOI:10.1021/jo101050z

Reference yield:

(2S,4R)-4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2H-pyran-2-carboxaldehyde + C28H45FN3O2PS (1246665-81-5) → N-(5-((E)-2-((2S,4R)-4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide + N-(4-(4-fluorophenyl)-6-isopropyl-5-methylpyrimidin-2-yl)-N-methylmethanesulfonamide (953776-62-0) + (S,E)-N-(4-(4-fluorophenyl)-6-isopropyl-5-(2-(6-oxo-3,6-dihydro-2H-pyran-2-yl)vinyl)pyrimidin-2-yl)-N-methylmethanesulfonamide (1246665-85-9) + N-(5-((Z)-2-((2S,4R)-4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide (1246665-84-8)

Guidance literature:

In toluene; at 65 ℃;

DOI:10.1021/jo101050z

upstream raw materials:

C₂₈H₄₅FN₃O₂PS

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