Cas 1246665-84-8,N-(5-((Z)-2-((2S,4R)-4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide

1246665-84-8

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Product Name: N-(5-((Z)-2-((2S,4R)-4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide
Synonyms: N-(5-((Z)-2-((2S,4R)-4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide
CAS NO:1246665-84-8
Molecular Formula:
Molecular Weight: 577.793
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: N-(5-((Z)-2-((2S,4R)-4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide(CAS DataBase Reference)
NIST Chemistry Reference: N-(5-((Z)-2-((2S,4R)-4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide(1246665-84-8)
EPA Substance Registry System: N-(5-((Z)-2-((2S,4R)-4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide(1246665-84-8)

Safety Data

Hazard Codes: N/A
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Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1246665-84-8(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1246665-84-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,6,6,6 and 5 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1246665-84:
(9*1)+(8*2)+(7*4)+(6*6)+(5*6)+(4*6)+(3*5)+(2*8)+(1*4)=178
178 % 10 = 8
So 1246665-84-8 is a valid CAS Registry Number.

1246665-84-8Upstream product

1246665-84-8Downstream Products

1444772-05-7 N-(4-(4-fluorophenyl)-5-((Z)-2-((2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide

1246665-84-8Relevant academic research and scientific papers

Lactone pathway to statins utilizing the wittig reaction. the synthesis of rosuvastatin

Casar, Zdenko,Steinbuecher, Miha,Kosmrlj, Janez

scheme or table, p. 6681 - 6684 (2010/12/19)

The first entry to statins via lactonized side chain is reported, exemplified by the synthesis of rosuvastatin. The key step is Wittig coupling of (2S,4R)-4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2H-pyran-2-carbaldehyde and phosphonium salt of an appropriately functionalized pyrimidine heterocy'le. One-pot deprotection and hydrolysis of the resulting 4-O-TBS rosuvastatin lactone provided rosuvastatin in high yield.

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