Ezetimibe Impurity

Base Information

Chemical Name:Ezetimibe Impurity
CAS No.:1510820-22-0
Molecular Formula:C₂₄H₂₃F₂NO₂
Molecular Weight:395.449
Hs Code.:

Synonyms:

Suppliers and Price of Ezetimibe Impurity

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of Ezetimibe Impurity

Chemical Property:

Boiling Point:610.4±55.0 °C(Predicted)
PKA:10.04±0.15(Predicted)
Density:1.246±0.06 g/cm3(Predicted)
Solubility.:Dichloromethane; DMSO; Ethyl Acetate

Purity/Quality:: NLT 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 3-Dehydroxy Ezetimibe Open Ring Impurity is an impurity in the synthesis of 3-Dehydroxy Ezetimibe, a derivative of Ezetimibe (E975000), an antihyperlipoproteinemic. A cholesterol absorption inhibitor.

Technology Process of Ezetimibe Impurity

There total 9 articles about Ezetimibe Impurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 4-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-[3-(4-fluorophenyl)propyl]-2-azetidinone

: 204589-58-2
1-(4-fluorophenyl)-[3-(4-fluorophenyl)propyl]-4-(4-hydroxyphenyl)-2-azetidinone

: 1510820-22-0
N-(4-fluorophenyl)-5-(4-fluorophenyl)-2-(4-hydroxybenzyl)pentanamide

Guidance literature:: With ammonium formate; palladium on activated charcoal; In methanol; Heating;

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 1510820-22-0
N-(4-fluorophenyl)-5-(4-fluorophenyl)-2-(4-hydroxybenzyl)pentanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / toluene / 48 h / Heating

2: 48 percent / tributylamine / toluene / 72 h / Heating

3: 20 percent / ammonium formate / 10 percent Pd/C / methanol / Heating

With tributyl-amine; ammonium formate; palladium on activated charcoal; In methanol; toluene;

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1510820-22-0
N-(4-fluorophenyl)-5-(4-fluorophenyl)-2-(4-hydroxybenzyl)pentanamide

Guidance literature:: Multi-step reaction with 6 steps

1: 62 percent / potassium hydroxide / ethanol / 48 h / 20 °C

2: 73 percent / NiCl₂*6H₂O; sodium borohydride / methanol / 12 h / 20 °C

3: 50 percent / 0.17 h / 170 - 180 °C

4: 97 percent / oxalyl chloride / CH₂Cl₂ / 2 h / Heating

5: 48 percent / tributylamine / toluene / 72 h / Heating

6: 20 percent / ammonium formate / 10 percent Pd/C / methanol / Heating

With potassium hydroxide; sodium tetrahydroborate; oxalyl dichloride; tributyl-amine; ammonium formate; nickel dichloride; palladium on activated charcoal; In methanol; ethanol; dichloromethane; toluene;