EzetiMibe Dehydoxy IMpurity

Base Information

• Chemical Name: EzetiMibe Dehydoxy IMpurity
• CAS No.: 204589-58-2
• Molecular Formula: C₂₄H₂₁F₂NO₂
• Molecular Weight: 393.433
• Mol file: 204589-58-2.mol

Synonyms:

Chemical Property of EzetiMibe Dehydoxy IMpurity

Chemical Property:

• Boiling Point: 614.9±55.0 °C(Predicted)
• PKA: 9.72±0.30(Predicted)
• Density: 1.275±0.06 g/cm3(Predicted)

Purity/Quality:

NLT 98% ^*data from raw suppliers

3-DehydroxyEzetimibe ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3-Dehydroxy Ezetimibe is a derivative of Ezetimibe (E975000), an antihyperlipoproteinemic. A cholesterol absorption inhibitor.

Technology Process of EzetiMibe Dehydoxy IMpurity

There total 19 articles about EzetiMibe Dehydoxy IMpurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-[3-(4-fluorophenyl)propyl]-2-azetidinone → 1-(4-fluorophenyl)-[3-(4-fluorophenyl)propyl]-4-(4-hydroxyphenyl)-2-azetidinone (204589-58-2) + N-(4-fluorophenyl)-5-(4-fluorophenyl)-2-(4-hydroxybenzyl)pentanamide (1510820-22-0)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; Heating;

Reference yield:

1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-2-E-propenyl]-4-(4-hydroxyphenyl)-2-azetidinone (204589-68-4) → 1-(4-fluorophenyl)-[3-(4-fluorophenyl)propyl]-4-(4-hydroxyphenyl)-2-azetidinone (204589-58-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 2h; under 760 Torr;

DOI:10.1016/S0040-4020(00)00429-4

Reference yield:

(3R,4S)-4-(4-Benzyloxy-phenyl)-1-(4-fluoro-phenyl)-3-[3-(4-fluoro-phenyl)-propyl]-azetidin-2-one (204589-96-8) → 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)propyl]-(4S)-(4-hydroxyphenyl)-2-azetidinone (204589-58-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; for 4h; under 3102.9 Torr; Ambient temperature;

DOI:10.1021/jm970701f

upstream raw materials:

(3R,4S)-4-(4-Benzyloxy-phenyl)-1-(4-fluoro-phenyl)-3-[3-(4-fluoro-phenyl)-propyl]-azetidin-2-one

pent-4-enoic acid

4-fluoro-1-iodobenzene

5-(4-fluorophenyl)-3-pentenoic acid