PI3Kα inhibitor 1

Base Information

• Chemical Name: PI3Kα inhibitor 1
• CAS No.: 1235449-52-1
• Molecular Formula: C₂₃H₂₅N₉O₃S
• Molecular Weight: 507.576
• Mol file: 1235449-52-1.mol

Synonyms:

Chemical Property of PI3Kα inhibitor 1

Chemical Property:

Purity/Quality:

99%+, ^*data from raw suppliers

BEBT-908（CUDC-908） >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of PI3Kα inhibitor 1

There total 12 articles about PI3Kα inhibitor 1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.9%

ethyl 2-[methyl({2-[6-(methylamino)pyridin-3-yl]-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl}methyl)amino]pyrimidine-5-carboxylate → N-hydroxy-2-(methyl((2-(6-(methylamino)pyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)amino)pyrimidine-5-carboxamide (1235449-52-1)

Guidance literature:

With hydroxylamine hydrochloride; In methanol; dichloromethane; at 10 - 20 ℃; for 2.5h; Large scale;

Reference yield: 14.0%

→ N-hydroxy-2-(methyl((2-(6-(methylamino)pyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)amino)pyrimidine-5-carboxamide (1235449-52-1)

Guidance literature:

With hydroxylamine hydrochloride; potassium hydroxide; In methanol; dichloromethane; at 20 ℃; for 14h; Sealed tube;

Reference yield:

[6-(methylamino)pyridin-3-yl]boronic acid hydrochloride → N-hydroxy-2-(methyl((2-(6-(methylamino)pyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)amino)pyrimidine-5-carboxamide (1235449-52-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate / water; 1,4-dioxane / 90 - 95 °C / Inert atmosphere; Large scale

2: hydroxylamine hydrochloride / methanol; dichloromethane / 2.5 h / 10 - 20 °C / Large scale

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; hydroxylamine hydrochloride; palladium diacetate; potassium carbonate; In 1,4-dioxane; methanol; dichloromethane; water;

upstream raw materials:

1H-thieno[3,2-d]pyrimidine-2,4-dione

2,4-dichlorothieno[3,2-d]pyrimidine

2-chloro-4-morpholinothieno[3,2-d]pyrimidine

2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

Refernces

• 1、 -. "Thiophene pyrimidines and preparation and its preparation method and application". . . Retrieved 2017/08/22.