(3aS,10bS,12bS)-6-(4-Methoxy-benzenesulfonyl)-3a-methyl-11-phenylsulfanyl-2,3,3a,4,6,12b-hexahydro-1H-6,12a-diaza-indeno[7,1-cd]fluoren-12-one

Base Information

Chemical Name:(3aS,10bS,12bS)-6-(4-Methoxy-benzenesulfonyl)-3a-methyl-11-phenylsulfanyl-2,3,3a,4,6,12b-hexahydro-1H-6,12a-diaza-indeno[7,1-cd]fluoren-12-one
CAS No.:128592-39-2
Molecular Formula:C₃₁H₃₀N₂O₄S₂
Molecular Weight:558.722
Hs Code.:

(3aS,10bS,12bS)-6-(4-Methoxy-benzenesulfonyl)-3a-methyl-11-phenylsulfanyl-2,3,3a,4,6,12b-hexahydro-1H-6,12a-diaza-indeno[7,1-cd]fluoren-12-one

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Chemical Property of (3aS,10bS,12bS)-6-(4-Methoxy-benzenesulfonyl)-3a-methyl-11-phenylsulfanyl-2,3,3a,4,6,12b-hexahydro-1H-6,12a-diaza-indeno[7,1-cd]fluoren-12-one

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Technology Process of (3aS,10bS,12bS)-6-(4-Methoxy-benzenesulfonyl)-3a-methyl-11-phenylsulfanyl-2,3,3a,4,6,12b-hexahydro-1H-6,12a-diaza-indeno[7,1-cd]fluoren-12-one

There total 11 articles about (3aS,10bS,12bS)-6-(4-Methoxy-benzenesulfonyl)-3a-methyl-11-phenylsulfanyl-2,3,3a,4,6,12b-hexahydro-1H-6,12a-diaza-indeno[7,1-cd]fluoren-12-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7031-27-8
(phenylthio)acetic acid chloride

: 128592-39-2,128608-37-7
(3aS,10bS,12bS)-6-(4-Methoxy-benzenesulfonyl)-3a-methyl-11-phenylsulfanyl-2,3,3a,4,6,12b-hexahydro-1H-6,12a-diaza-indeno[7,1-cd]fluoren-12-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1N NaOH / 0.33 h / 0 °C

2: 100 percent / TFA / CH₂Cl₂ / 0.17 h / 0 °C

3: 95 percent / NaIO₄ / tetrahydrofuran; methanol; H₂O / 24 h

4: 1) TFAA / 1) 0 deg C 2) PhCl, 1h, reflux

With sodium hydroxide; sodium periodate; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/S0040-4039(00)94654-9

Reference yield:

: 128592-33-6
(R)-3-(3-Hydroxy-propyl)-3-methyl-1,2,3,9-tetrahydro-carbazol-4-one

: 128592-39-2,128608-37-7
(3aS,10bS,12bS)-6-(4-Methoxy-benzenesulfonyl)-3a-methyl-11-phenylsulfanyl-2,3,3a,4,6,12b-hexahydro-1H-6,12a-diaza-indeno[7,1-cd]fluoren-12-one

Guidance literature:: Multi-step reaction with 9 steps

1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: NaN₃ / dimethylformamide / 3 h / 80 °C

3: 93 percent / 50percent NaOH, n-Bu₄N*HSO₄ / CH₂Cl₂ / 2 h / 20 °C

4: 80 percent / NaBH₄ / ethanol / 0.17 h / Heating

5: 1) Ph₃P 2) H₂O / 1) THF, 48h, 20 deg C

6: 1N NaOH / 0.33 h / 0 °C

7: 100 percent / TFA / CH₂Cl₂ / 0.17 h / 0 °C

8: 95 percent / NaIO₄ / tetrahydrofuran; methanol; H₂O / 24 h

9: 1) TFAA / 1) 0 deg C 2) PhCl, 1h, reflux

With sodium hydroxide; sodium tetrahydroborate; sodium periodate; sodium azide; water; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; triphenylphosphine; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)94654-9

Reference yield:

: 128592-32-5
3-((R)-3-Methyl-4-oxo-2,3,4,9-tetrahydro-1H-carbazol-3-yl)-propionic acid methyl ester

: 128592-39-2,128608-37-7
(3aS,10bS,12bS)-6-(4-Methoxy-benzenesulfonyl)-3a-methyl-11-phenylsulfanyl-2,3,3a,4,6,12b-hexahydro-1H-6,12a-diaza-indeno[7,1-cd]fluoren-12-one

Guidance literature:: Multi-step reaction with 10 steps

1: 87 percent / LiEt₃BH / tetrahydrofuran / 1 h / -10 °C

2: Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: NaN₃ / dimethylformamide / 3 h / 80 °C

4: 93 percent / 50percent NaOH, n-Bu₄N*HSO₄ / CH₂Cl₂ / 2 h / 20 °C

5: 80 percent / NaBH₄ / ethanol / 0.17 h / Heating

6: 1) Ph₃P 2) H₂O / 1) THF, 48h, 20 deg C

7: 1N NaOH / 0.33 h / 0 °C

8: 100 percent / TFA / CH₂Cl₂ / 0.17 h / 0 °C

9: 95 percent / NaIO₄ / tetrahydrofuran; methanol; H₂O / 24 h

10: 1) TFAA / 1) 0 deg C 2) PhCl, 1h, reflux

With sodium hydroxide; sodium tetrahydroborate; sodium periodate; sodium azide; water; tetra(n-butyl)ammonium hydrogensulfate; lithium triethylborohydride; triethylamine; triphenylphosphine; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)94654-9