2-[(benzylcarbamoyl)methyl]-1-[(3,4-dimethoxyphenyl)methyl]-6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-yl 7-[(7-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]formamido}heptyl)(methyl)amino]heptanoate

Base Information

Chemical Name:2-[(benzylcarbamoyl)methyl]-1-[(3,4-dimethoxyphenyl)methyl]-6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-yl 7-[(7-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]formamido}heptyl)(methyl)amino]heptanoate
CAS No.:1584647-04-0
Molecular Formula:C₆₀H₇₁Cl₃N₆O₇
Molecular Weight:1094.62
Hs Code.:

2-[(benzylcarbamoyl)methyl]-1-[(3,4-dimethoxyphenyl)methyl]-6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-yl 7-[(7-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]formamido}heptyl)(methyl)amino]heptanoate

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Chemical Property of 2-[(benzylcarbamoyl)methyl]-1-[(3,4-dimethoxyphenyl)methyl]-6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-yl 7-[(7-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]formamido}heptyl)(methyl)amino]heptanoate

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Technology Process of 2-[(benzylcarbamoyl)methyl]-1-[(3,4-dimethoxyphenyl)methyl]-6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-yl 7-[(7-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]formamido}heptyl)(methyl)amino]heptanoate

There total 9 articles about 2-[(benzylcarbamoyl)methyl]-1-[(3,4-dimethoxyphenyl)methyl]-6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-yl 7-[(7-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]formamido}heptyl)(methyl)amino]heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 361388-49-0
N-benzyl-2-{1-[(3,4-dimethoxyphenyl)methyl]-7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinolin-2-yl}acetamide

: 1584647-16-4
7-[(7-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]formamido}heptyl)(methyl)amino]heptanoic acid

: 1584647-04-0
2-[(benzylcarbamoyl)methyl]-1-[(3,4-dimethoxyphenyl)methyl]-6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-yl 7-[(7-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]formamido}heptyl)(methyl)amino]heptanoate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 2,2,2-trifluoroethanol; Inert atmosphere;
DOI:10.1021/ml4004759

Reference yield:

: 554-52-9
3-Methoxytyramine

: 1584647-04-0
2-[(benzylcarbamoyl)methyl]-1-[(3,4-dimethoxyphenyl)methyl]-6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-yl 7-[(7-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]formamido}heptyl)(methyl)amino]heptanoate

Guidance literature:: Multi-step reaction with 5 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

2: trichlorophosphate / toluene

3: sodium tetrahydroborate; methanol

4: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide

5: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / 2,2,2-trifluoroethanol / Inert atmosphere

With methanol; sodium tetrahydroborate; tetra-(n-butyl)ammonium iodide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 2,2,2-trifluoroethanol; N,N-dimethyl-formamide; toluene; 2: |Bischler-Napieralski Reaction;
DOI:10.1021/ml4004759

Reference yield:

: 1338604-42-4
N-(7-aminoheptyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

: 1584647-04-0
2-[(benzylcarbamoyl)methyl]-1-[(3,4-dimethoxyphenyl)methyl]-6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-yl 7-[(7-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]formamido}heptyl)(methyl)amino]heptanoate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / toluene / Reflux

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane; water / 2 h / 20 °C

3: sodium hydroxide; water / ethanol / 20 °C

4: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / 2,2,2-trifluoroethanol / Inert atmosphere

With water; sodium tris(acetoxy)borohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; 2,2,2-trifluoroethanol; water; 1,2-dichloro-ethane; toluene;
DOI:10.1021/ml4004759