C₁₆H₁₉NO₃S

Base Information

• Chemical Name: C₁₆H₁₉NO₃S
• CAS No.: 1380242-07-8
• Molecular Formula: C₁₆H₁₉NO₃S
• Molecular Weight: 305.398
• Mol file: 1380242-07-8.mol

Synonyms:

Chemical Property of C₁₆H₁₉NO₃S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₉NO₃S

There total 1 articles about C₁₆H₁₉NO₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

acrolein (107-02-8,25068-14-8) + (R)-1-(4-benzyl-2-thioxooxazolidin-3-yl)propan-1-one (334968-78-4) → C16H19NO3S (1380242-07-8)

Guidance literature:

With titanium tetrachloride; (-)-sparteine; In dichloromethane; for 4h; Cooling with ice; Inert atmosphere;

DOI:10.1002/anie.201201395

Reference yield:

C16H19NO3S (1380242-07-8) → C30H37NO7 (1380242-05-6)

Guidance literature:

Multi-step reaction with 9 steps

1.1: diisobutylaluminium hydride / dichloromethane; cyclohexane / 1 h / -78 °C / Inert atmosphere

1.2: 4 h / 20 °C / Cooling with ice

2.1: triethylamine / dichloromethane / 1 h / Cooling with ice

3.1: N,N,N,N,N,N-hexamethylphosphoric triamide; tert.-butyl lithium / tetrahydrofuran; pentane / 0.5 h / -78 - -40 °C / Inert atmosphere

4.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / -10 °C / Inert atmosphere

5.1: camphor-10-sulfonic acid / methanol; dichloromethane / 1 h / -10 °C

6.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 2 h / Cooling with ice; Inert atmosphere

7.1: 1-methyl-pyrrolidin-2-one; titanium tetrachloride; sparteine / dichloromethane / 2 h / -78 - 0 °C / Inert atmosphere

8.1: bis-[(trifluoroacetoxy)iodo]benzene / methanol; water / 0.08 h / Cooling with ice

9.1: hydrogen fluoride / water; acetonitrile / 0.5 h / 20 °C

With 1-methyl-pyrrolidin-2-one; N,N,N,N,N,N-hexamethylphosphoric triamide; camphor-10-sulfonic acid; hydrogen fluoride; tert.-butyl lithium; sodium hexamethyldisilazane; sulfur trioxide pyridine complex; titanium tetrachloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; bis-[(trifluoroacetoxy)iodo]benzene; sparteine; In tetrahydrofuran; methanol; dichloromethane; cyclohexane; water; N,N-dimethyl-formamide; acetonitrile; pentane;

DOI:10.1002/anie.201201395

Reference yield:

C16H19NO3S (1380242-07-8) → C33H60O3S2Si2 (1380242-10-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / dichloromethane; cyclohexane / 1 h / -78 °C / Inert atmosphere

1.2: 4 h / 20 °C / Cooling with ice

2.1: triethylamine / dichloromethane / 1 h / Cooling with ice

3.1: N,N,N,N,N,N-hexamethylphosphoric triamide; tert.-butyl lithium / tetrahydrofuran; pentane / 0.5 h / -78 - -40 °C / Inert atmosphere

4.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / -10 °C / Inert atmosphere

With N,N,N,N,N,N-hexamethylphosphoric triamide; tert.-butyl lithium; sodium hexamethyldisilazane; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; dichloromethane; cyclohexane; N,N-dimethyl-formamide; pentane;

DOI:10.1002/anie.201201395

upstream raw materials:

acrolein

(R)-1-(4-benzyl-2-thioxooxazolidin-3-yl)propan-1-one

Downstream raw materials:

C₃₀H₃₇NO₇

C₅₀H₆₇NO₁₁

C₅₀H₆₇NO₁₁

C₃₃H₆₀O₃S₂Si₂