Technology Process of N5,1-Dibenzoyl-N5-(phenylsulfonyl)-5-amino-6-(benzyloxy)-2-methylindole-3-carboxylic Acid Methyl Ester
There total 16 articles about N5,1-Dibenzoyl-N5-(phenylsulfonyl)-5-amino-6-(benzyloxy)-2-methylindole-3-carboxylic Acid Methyl Ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 85 percent / K2CO3, tetra-n-butylammonium iodide / acetone / 20 h / Heating
2: 69 percent / sodium dithionite / tetrahydrofuran; H2O / 24 h / Heating
3: 90 percent / K2CO3 / tetrahydrofuran / 0.17 h / 25 °C
4: 88 percent / trifluoroacetic acid (0.25 M in CH2Cl2) / CH2Cl2 / 0.5 h / 25 °C
5: 79 percent / pyridine / tetrahydrofuran / 20 h / Heating
6: 93 percent / lead tetraacetate / CHCl3 / 6 h / 25 °C
7: 98 percent / sodium methoxide / tetrahydrofuran / 1 h / -20 °C
8: 88 percent / H2SO4 (20percent in CH2Cl2) / CH2Cl2
9: 1) KH / 1) THF, 25 deg C, 0.5 h, 2) 25 deg C, 6 h
With
pyridine; lead(IV) acetate; sodium dithionite; sulfuric acid; sodium methylate; tetra-(n-butyl)ammonium iodide; potassium hydride; potassium carbonate; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; chloroform; water; acetone;
DOI:10.1021/jo00291a059
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 90 percent / K2CO3 / tetrahydrofuran / 0.17 h / 25 °C
2: 88 percent / trifluoroacetic acid (0.25 M in CH2Cl2) / CH2Cl2 / 0.5 h / 25 °C
3: 79 percent / pyridine / tetrahydrofuran / 20 h / Heating
4: 93 percent / lead tetraacetate / CHCl3 / 6 h / 25 °C
5: 98 percent / sodium methoxide / tetrahydrofuran / 1 h / -20 °C
6: 88 percent / H2SO4 (20percent in CH2Cl2) / CH2Cl2
7: 1) KH / 1) THF, 25 deg C, 0.5 h, 2) 25 deg C, 6 h
With
pyridine; lead(IV) acetate; sulfuric acid; sodium methylate; potassium hydride; potassium carbonate; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1021/jo00291a059
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 79 percent / pyridine / tetrahydrofuran / 20 h / Heating
2: 93 percent / lead tetraacetate / CHCl3 / 6 h / 25 °C
3: 98 percent / sodium methoxide / tetrahydrofuran / 1 h / -20 °C
4: 88 percent / H2SO4 (20percent in CH2Cl2) / CH2Cl2
5: 1) KH / 1) THF, 25 deg C, 0.5 h, 2) 25 deg C, 6 h
With
pyridine; lead(IV) acetate; sulfuric acid; sodium methylate; potassium hydride;
In
tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1021/jo00291a059
