7-Nitro-1,2,3,4-tetrahydronaphthalen-1-ol

Base Information

• Chemical Name: 7-Nitro-1,2,3,4-tetrahydronaphthalen-1-ol
• CAS No.: 32820-11-4
• Molecular Formula: C₁₀H₁₁NO₃
• Molecular Weight: 193.202
• DSSTox Substance ID: DTXSID50451689
• Mol file: 32820-11-4.mol

Synonyms:7-nitro-1,2,3,4-tetrahydronaphthalen-1-ol;32820-11-4;1-Hydroxy-7-nitro-tetralin;7-nitro-1,2,3,4-tetrahydro-1-naphthalenol;SCHEMBL394579;DTXSID50451689;GTNBTXJNXZBVJP-UHFFFAOYSA-N;7-nitro-1,2,3,4-tetrahydro-naphthalen-1-ol;EN300-200481

Chemical Property of 7-Nitro-1,2,3,4-tetrahydronaphthalen-1-ol

Chemical Property:

• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 193.07389321
• Heavy Atom Count: 14
• Complexity: 226

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(C2=C(C1)C=CC(=C2)[N+](=O)[O-])O

Technology Process of 7-Nitro-1,2,3,4-tetrahydronaphthalen-1-ol

There total 1 articles about 7-Nitro-1,2,3,4-tetrahydronaphthalen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-nitro-3,4-dihydro-2H-naphthalen-1-one (40353-34-2) → 7-amino-1,2,3,4-tetrahydronaphthalen-1-ol (214698-03-0) + 7-nitro-1,2,3,4-tetrahydronaphthalen-1-ol (32820-11-4) + 7-amino-1-tetralone (22009-40-1)

Guidance literature:

With hydrogen; In ethanol; at 140 ℃; for 6h; under 18241.2 Torr; Autoclave;

DOI:10.1002/cctc.201801247

Reference yield: 95.0%

7-nitro-1,2,3,4-tetrahydronaphthalen-1-ol (32820-11-4) → 7-amino-1,2,3,4-tetrahydronaphthalen-1-ol (214698-03-0)

Guidance literature:

Pd-C; In methanol;

Reference yield:

7-nitro-1,2,3,4-tetrahydronaphthalen-1-ol (32820-11-4) → C26H28N2O5S

Guidance literature:

Multi-step reaction with 6 steps

1: TsOH / toluene

2: m-CPBA / CH₂Cl₂

3: NH₄OH

4: Et₃N / CH₂Cl₂

5: SnCl₂*2H₂O / ethanol

6: Et₃N / CH₂Cl₂

With ammonium hydroxide; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; tin(ll) chloride; In ethanol; dichloromethane; toluene;

DOI:10.1016/j.bmcl.2007.02.052

upstream raw materials:

7-nitro-3,4-dihydro-2H-naphthalen-1-one

Downstream raw materials:

7-Nitro-3,4-dihydro-2(1H)-naphthaleneone

5,6,7,8-tetrahydronaphthalene-1,4-diol

7-amino-1,2,3,4-tetrahydronaphthalen-1-ol

1-bromo-7-nitro-1,2,3,4-tetrahydronaphthalene