40353-34-2

Usage

InChI:InChI=1/C10H9NO3/c12-10-3-1-2-7-4-5-8(11(13)14)6-9(7)10/h4-6H,1-3H2

Upstream product

• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 1821-12-1 4-Phenylbutyric acid 
• 7697-37-2 nitric acid 
• 771-29-9 1,2,3,4-tetrahydro-1-naphthyl hydroperoxide 
• 89781-52-2 8-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid 

Downstream Products

• 22009-40-1 7-amino-1-tetralone 
• 19256-82-7 7-nitronaphthalen-1-ol 
• 58490-99-6 7-nitro-3,4-dihydro-2H-naphthalen-1-one oxime 
• 106824-80-0 5,6,7,8-Tetrahydrobenzisatin 
• 106824-79-7 6,7,8,9-Tetrahydrobenzisatin 
• 2217-43-8 6-amino-1,2,3,4-tetrahydronaphthalene 
• 52092-49-6 1-Methoxy-7-nitronaphthalin 
• 92287-47-3 8-methoxy-2-naphthylamine 
• 376350-13-9 N-(8-Nitro-4,5-dihydronaphtho[1,2-d][1,3]thiazol-2-yl)[1,1'-biphenyl]-4-sulfonamide 
• 376350-11-7 N-(8-Nitro-4,5-dihydronaphtho[1,2-d][1,3]thiazol-2-yl)-4-propylbenzenesulfonamide 
• 376350-12-8 N-(8-Nitro-4,5-dihydronaphtho[1,2-d][1,3]thiazol-2-yl)benzenesulfonamide 
• 22246-79-3 8-nitro-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one 
• 214698-03-0 7-amino-1,2,3,4-tetrahydronaphthalen-1-ol 
• 1403886-64-5 ethyl 1-(4-fluorophenyl)-8-nitro-4,5-dihydro-1H-benzo[g]indazole-3-carboxylate 

Relevant academic research and scientific papers

Improved Receptors for Dibutylmalonic Acid

New molecular receptors with a dibenzacridine skeleton bearing functional groups complementary to dibutylmalonic acid have been developed.

Synthesis and biological evaluation of a series of aminoalkyl-tetralones and tetralols as dual dopamine/serotonin ligands

A series of novel α-tetralone and α-tetralol derivatives was synthesized, and their binding affinities for 5-HT2A and D 2 receptors, the most important targets implicated in the anti-schizophrenia drug action, were evaluated to eluci

Chirochromism-photochromism by epimerization: Search for a liquid crystal phototrigger

A new class of photochromic reactions was investigated as a possible trigger for phase transitions in liquid crystals. Chirochromic compounds have two chiral units. One unit is fixed, and the other can be switched with light. A series of diastereomeric co

Substituted 9-Diethylaminobenzo[ a]phenoxazin-5-ones (Nile Red Analogues): Synthesis and Photophysical Properties

Nile Red is a benzo[a]phenoxazone dye containing a diethylamino substituent at the 9-position. In recent years, it has become a popular histological stain for cellular membranes and lipid droplets due to its unrivaled fluorescent properties in lipophilic environments. This makes it an attractive lead for chemical decoration to tweak its attributes and optimize it for more specialized microscopy techniques, e.g., fluorescence lifetime imaging or two-photon excited fluorescence microscopy, to which Nile Red has never been optimized. Herein, we present synthesis approaches to a series of monosubstituted Nile Red derivatives (9-diethylbenzo[a]phenoxazin-5-ones) starting from 1-naphthols or 1,3-naphthalenediols. The solvatochromic responsiveness of these fluorophores is reported with focus on how the substituents affect the absorption and emission spectra, luminosity, fluorescence lifetimes, and two-photon absorptivity. Several of the analogues emerge as strong candidates for reporting the polarity of their local environment. Specifically, the one- and two-photon excited fluorescence of Nile Red turns out to be very responsive to substitution, and the spectroscopic features can be finely tuned by judiciously introducing substituents of distinct electronic character at specific positions. This new toolkit of 9-diethylbenzo[a]phenoxazine-5-ones constitutes a step toward the next generation of optical molecular probes for advancing the understanding of lipid structures and cellular processes.

METHODS FOR MAKING QUINOLINYLDIAMINES

The present disclosure provides methods for making quinolinyldiamine products from quinolinyl starting materials. In addition, the quinolinyldiamines can be used as ligands or ligand precursors for catalysts, e.g. for use in olefin polymerization.

THERAPEUTIC COMPOUNDS

The invention provides compounds of formula (I): wherein, A, C, D, X, and Y have any of the values defined in the specification, and salts thereof. The compounds are SIRT2 inhibitors and are useful for treating SIRT2 associated conditions.

Silver(I)-Promoted ipso-Nitration of Carboxylic Acids by Nitronium Tetrafluoroborate

A novel and efficient method for the regioselective nitration of a series of aliphatic and aromatic carboxylic acids to their corresponding nitro compounds using nitronium tetrafluoroborate and silver carbonate in dimethylacetamide has been described. This transformation is believed to proceed via the alkyl-silver or aryl-silver intermediate, which subsequently reacts with the nitronium ion to form nitro substances. Mild reaction conditions, tolerant of a broad range of functional groups, and formation of only the ipso-nitrated products are the key features of this methodology when compared to known methods for syntheses of nitroalkyls and nitroarenes.

NOVEL THIENOPYRIMIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND THERAPEUTIC USES THEREOF

The present invention relates to compounds of formula (I): wherein R6 is —CONH2 or a —C(Rα)(Rβ)(OH) group; R is a substituted phenyl or heteroaryl group; R7 is an optionally substituted aryl or heteroaryl group. Process for the preparation thereof and therapeutic use thereof.

NOVEL THIENOPYRIMIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND THERAPEUTIC USES THEREOF

The present invention relates to compounds of formula (I): wherein R6 is -CONH2 or a -C(Rα)(Rβ)(OH) group; R is a substituted phenyl or heteroaryl group; R7 is an optionally substituted aryl or heteroaryl group. Process for the preparation thereof and therapeutic use thereof.

Tricyclic [1,2,4]triazine 1,4-dioxides as hypoxia selective cytotoxins

A series of novel tricyclic triazine-di-N-oxides (TTOs) related to tirapazamine have been designed and prepared. A wide range of structural arrangements with cycloalkyl, oxygen-, and nitrogen-containing saturated rings fused to the triazine core, coupled with various side chains linked to either hemisphere, resulted in TTO analogues that displayed hypoxia-selective cytotoxicity in vitro. Optimal rates of hypoxic metabolism and tissue diffusion coefficients were achieved with fused cycloalkyl rings in combination with both the 3-aminoalkyl or 3-alkyl substituents linked to weakly basic soluble amines. The selection was further refined using pharmacokinetic/pharmacodynamic model predictions of the in vivo hypoxic potency (AUCreq) and selectivity (HCD) with 12 TTO analogues predicted to be active in vivo, subject to the achievement of adequate plasma pharmacokinetics.