Ac-L-Phe-L-Phe-NH₂

Base Information

Chemical Name:Ac-L-Phe-L-Phe-NH₂
CAS No.:60731-30-8
Molecular Formula:C₁₈H₂₁N₃O₃
Molecular Weight:327.383
Hs Code.:

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Chemical Property of Ac-L-Phe-L-Phe-NH₂

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Technology Process of Ac-L-Phe-L-Phe-NH₂

There total 3 articles about Ac-L-Phe-L-Phe-NH₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403821-04-4
C₂₇H₂₆N₂O₄

: 35661-40-6
N-Fmoc L-Phe

: 60731-30-8
Ac-L-Phe-L-Phe-NH₂

Guidance literature:: C₂₇H₂₆N₂O₄; With 2-Methyl-2-nitropropane; boron trifluoride diethyl etherate; In dichloromethane; at -10 ℃; for 1h; Inert atmosphere;

With pyridine; C₆H₁₀NOPol; In N,N-dimethyl-formamide; at -10 - 20 ℃; for 3h; MBHA-polystyrene resin Inert atmosphere;

N-Fmoc L-Phe; Further stages;
DOI:10.1021/jo301630h

Reference yield:

: 1403821-08-8
(S)-Fmoc-Phe(pNO₂)-Oallyl

: 60731-30-8
Ac-L-Phe-L-Phe-NH₂

Guidance literature:: Multi-step reaction with 2 steps

1.1: zinc; acetic acid / ethanol / 1 h / 60 °C

2.1: boron trifluoride diethyl etherate; 2-Methyl-2-nitropropane / dichloromethane / 1 h / -10 °C / Inert atmosphere

2.2: 3 h / -10 - 20 °C / Inert atmosphere

With 2-Methyl-2-nitropropane; boron trifluoride diethyl etherate; acetic acid; zinc; In ethanol; dichloromethane;
DOI:10.1021/jo301630h

Reference yield:

: 95753-55-2,177966-63-1
N-α-FMOC-4-nitro-L-phenylalanine

: 60731-30-8
Ac-L-Phe-L-Phe-NH₂

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: zinc; acetic acid / ethanol / 1 h / 60 °C

3.1: boron trifluoride diethyl etherate; 2-Methyl-2-nitropropane / dichloromethane / 1 h / -10 °C / Inert atmosphere

3.2: 3 h / -10 - 20 °C / Inert atmosphere

With 2-Methyl-2-nitropropane; boron trifluoride diethyl etherate; sodium hydrogencarbonate; acetic acid; zinc; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo301630h