(S)-1-[(S)-2-((S)-2-{(R)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-(4-hydroxy-phenyl)-propionylamino]-3-phenyl-propionylamino}-4-methyl-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carboxylic acid carbamoylmethyl-amide

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Chemical Name:(S)-1-[(S)-2-((S)-2-{(R)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-(4-hydroxy-phenyl)-propionylamino]-3-phenyl-propionylamino}-4-methyl-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carboxylic acid carbamoylmethyl-amide
CAS No.:132478-01-4
Molecular Formula:C₄₀H₅₉N₁₁O₉
Molecular Weight:837.977
Hs Code.:

(S)-1-[(S)-2-((S)-2-{(R)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-(4-hydroxy-phenyl)-propionylamino]-3-phenyl-propionylamino}-4-methyl-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carboxylic acid carbamoylmethyl-amide

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Chemical Property of (S)-1-[(S)-2-((S)-2-{(R)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-(4-hydroxy-phenyl)-propionylamino]-3-phenyl-propionylamino}-4-methyl-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carboxylic acid carbamoylmethyl-amide

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Technology Process of (S)-1-[(S)-2-((S)-2-{(R)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-(4-hydroxy-phenyl)-propionylamino]-3-phenyl-propionylamino}-4-methyl-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carboxylic acid carbamoylmethyl-amide

There total 19 articles about (S)-1-[(S)-2-((S)-2-{(R)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-(4-hydroxy-phenyl)-propionylamino]-3-phenyl-propionylamino}-4-methyl-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carboxylic acid carbamoylmethyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2666-93-5
(S)-Leu-OMe

: 132478-01-4
(S)-1-[(S)-2-((S)-2-{(R)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-(4-hydroxy-phenyl)-propionylamino]-3-phenyl-propionylamino}-4-methyl-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carboxylic acid carbamoylmethyl-amide

Guidance literature:: Multi-step reaction with 7 steps

2: hydrogen bromide / dimethylformamide

4: NH₂NH₂

5: HNO₂

7: H₂ / catalytic hydrog.

With hydrogen bromide; hydrogen; cis-nitrous acid; hydrazine; In N,N-dimethyl-formamide;
DOI:10.1007/BF00714941

Reference yield:

: 1234-35-1
Z-Arg-OH

: 132478-01-4
(S)-1-[(S)-2-((S)-2-{(R)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-(4-hydroxy-phenyl)-propionylamino]-3-phenyl-propionylamino}-4-methyl-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carboxylic acid carbamoylmethyl-amide

Guidance literature:: Multi-step reaction with 4 steps

2: hydrogen bromide / acetic acid

4: H₂ / catalytic hydrog.

With hydrogen bromide; hydrogen; In acetic acid;
DOI:10.1007/BF00714941

Reference yield:

: 35010-96-9
Nα-benzyloxycarbonyl-L-prolyl-glycinamide

: 132478-01-4
(S)-1-[(S)-2-((S)-2-{(R)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-(4-hydroxy-phenyl)-propionylamino]-3-phenyl-propionylamino}-4-methyl-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carboxylic acid carbamoylmethyl-amide

Guidance literature:: Multi-step reaction with 5 steps

1: H⁽¹⁺⁾

3: hydrogen bromide / acetic acid

5: H₂ / catalytic hydrog.

With hydrogen bromide; hydrogen; hydrogen cation; In acetic acid;
DOI:10.1007/BF00714941