CARBOBENZYLOXY-L-SERYL-L-TYROSINE METHYL ESTER

Base Information

• Chemical Name: CARBOBENZYLOXY-L-SERYL-L-TYROSINE METHYL ESTER
• CAS No.: 24118-03-4
• Molecular Formula: C21H24N2O7
• Molecular Weight: 416.42400
• Mol file: 24118-03-4.mol

Synonyms:CARBOBENZYLOXY-L-SERYL-L-TYROSINE METHYL ESTER;N-(N-Benzyloxycarbonyl-L-seryl)-L-tyrosin-methylester;N-(N-benzyloxycarbonyl-L-seryl)-L-tyrosine methyl ester;Z-Ser-Tyr-OMe;Benzyloxycarbonyl-seryl-tyrosin-methylester (L);

Chemical Property of CARBOBENZYLOXY-L-SERYL-L-TYROSINE METHYL ESTER

Chemical Property:

• PSA: 134.19000
• LogP: 1.66160

Purity/Quality:

99% ^*data from raw suppliers

CARBOBENZYLOXY-L-SERYL-L-TYROSINE METHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of CARBOBENZYLOXY-L-SERYL-L-TYROSINE METHYL ESTER

There total 6 articles about CARBOBENZYLOXY-L-SERYL-L-TYROSINE METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

N-(benzyloxycarbonyl)-L-serine (1145-80-8) + L-Tyr-OMe (1080-06-4) → Z-L-Ser-L-Tyr-OMe (24118-03-4)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide;

DOI:10.1021/ja00094a008

Reference yield:

benzyl (1S)-2-hydrazino-1-(hydroxymethyl)-2-oxoethylcarbamate (26582-86-5) → Z-L-Ser-L-Tyr-OMe (24118-03-4)

Guidance literature:

With hydrogenchloride; acetic acid; sodium nitrite; Behandeln des Reaktionsprodukts mit L-Tyrosin-methylester in Dioxan und Aethylacetat;

DOI:10.1021/ja01649a019

Reference yield:

L-tyrosine methyl ester HCl (3417-91-2) + N-(benzyloxycarbonyl)-L-serine pentachlorophenyl ester (13673-57-9) → Z-L-Ser-L-Tyr-OMe (24118-03-4)

Guidance literature:

With triethylamine; for 24h; Yield given;

DOI:10.1007/BF00630082

upstream raw materials:

N-(benzyloxycarbonyl)-L-serine

L-Tyr-OMe

benzyl (1S)-2-hydrazino-1-(hydroxymethyl)-2-oxoethylcarbamate

L-tyrosine methyl ester HCl

Downstream raw materials:

Z-L-Ser-L-Tyr-N₂H₃

Z-Ser-Tyr-OH

Z(OMe)-Gln-Ser-Tyr-OMe

HBr*H-L-Ser-L-Tyr-OMe