4-{4-[(2R)-2-(4-bromobenzenesulfonylamino)-2-tert-butoxycarbonyl-ethylsulfanyl]-2-methyl-pyrrolo[2,3-d]pyrimidin-7-yl}-butyric acid ethyl ester

Base Information

• Chemical Name: 4-{4-[(2R)-2-(4-bromobenzenesulfonylamino)-2-tert-butoxycarbonyl-ethylsulfanyl]-2-methyl-pyrrolo[2,3-d]pyrimidin-7-yl}-butyric acid ethyl ester
• CAS No.: 393544-87-1
• Molecular Formula: C₂₆H₃₃BrN₄O₆S₂
• Molecular Weight: 641.607

Synonyms:

Chemical Property of 4-{4-[(2R)-2-(4-bromobenzenesulfonylamino)-2-tert-butoxycarbonyl-ethylsulfanyl]-2-methyl-pyrrolo[2,3-d]pyrimidin-7-yl}-butyric acid ethyl ester

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Technology Process of 4-{4-[(2R)-2-(4-bromobenzenesulfonylamino)-2-tert-butoxycarbonyl-ethylsulfanyl]-2-methyl-pyrrolo[2,3-d]pyrimidin-7-yl}-butyric acid ethyl ester

There total 1 articles about 4-{4-[(2R)-2-(4-bromobenzenesulfonylamino)-2-tert-butoxycarbonyl-ethylsulfanyl]-2-methyl-pyrrolo[2,3-d]pyrimidin-7-yl}-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-chloro-2-methyl-pyrrolo[2,3-d]pyrimidin-7-yl)-butyric acid ethyl ester (393544-58-6) + N-(4-bromobenzenesulfonyl)-(R)-cysteine tert-butyl ester (393544-85-9) → 4-{4-[(2R)-2-(4-bromobenzenesulfonylamino)-2-tert-butoxycarbonyl-ethylsulfanyl]-2-methyl-pyrrolo[2,3-d]pyrimidin-7-yl}-butyric acid ethyl ester (393544-87-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 4h;

Reference yield: 15.0%

1,4,5,6-tetrahydro-pyrimidin-2-ylamine (41078-65-3) + 4-{4-[(2R)-2-(4-bromobenzenesulfonylamino)-2-tert-butoxycarbonyl-ethylsulfanyl]-2-methyl-pyrrolo[2,3-d]pyrimidin-7-yl}-butyric acid ethyl ester (393544-87-1) → (2R)-3-{2-methyl-7-[3-(1,4,5,6-tetrahydro-pyrimidin-2-ylcarbamoyl)-propyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylsulfanyl}-2-(4-bromobenzenesulfonylamino)-propionic acid tert-butyl ester (393544-89-3)

Guidance literature:

upstream raw materials:

4-(4-chloro-2-methyl-pyrrolo[2,3-d]pyrimidin-7-yl)-butyric acid ethyl ester

N-(4-bromobenzenesulfonyl)-(R)-cysteine tert-butyl ester

Downstream raw materials:

(2R)-3-{2-methyl-7-[3-(1,4,5,6-tetrahydro-pyrimidin-2-ylcarbamoyl)-propyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylsulfanyl}-2-(4-bromobenzenesulfonylamino)-propionic acid tert-butyl ester

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